Real World Outcomes in Patients With Recurrent, Advanced, or Metastatic Endometrial Cancer Treated With Lenvatinib Plus Pembrolizumab.

Aims: Patients with endometrial cancer who progress following first line therapy have improved survival outcomes with pembrolizumab and lenvatinib (pem/len) compared with standard of care chemotherapy, as demonstrated in KEYNOTE-775. This was in a group of trial patients with good performance status and excluded those with carcinosarcoma histology. In KEYNOTE-775 pem/len was associated with significant toxicity, leading to dose reductions, treatment cessation, and patient morbidity.

Prostatic abscess: an unusual cause of delirium associated with lower urinary tract symptoms.

Our case describes an 80-year-old gentleman who presented with delirium and lower urinary tract symptoms. Initially treated for a urinary tract infection, he became more unwell with features of physiological decompensation secondary to sepsis. A computerized tomography scan was performed in light of the findings of suprapubic tenderness, which on examination revealed a prostatic abscess.

Body weight loss, effective satiation and absence of homeostatic neuropeptide compensation in male Sprague Dawley rats schedule fed a protein crosslinked diet.

Food structure contributes to the induction of satiation and the maintenance of satiety following intake of a meal. There is evidence from human studies that protein-crosslinking of a milk-protein based meal may enhance satiety, but the mechanism underpinning this effect is unknown. We investigated whether a rat model would respond in a similar manner and might provide mechanistic insight into enhanced satiety by structural modification of a food source.

Colloidal particles in blue phase liquid crystals.

We study the effect of disorder on the phase transitions of a system already dominated by defects. Micron-sized colloidal particles are dispersed chiral nematic liquid crystals which exhibit a blue phase (BP). The colloids are a source of disorder, disrupting the liquid crystal as the system is heated from the cholesteric to the isotropic phase through the blue phase.

Colloidal templating at a cholesteric-oil interface: assembly guided by an array of disclination lines.

We simulate colloids (radius R ~ 1 μm) trapped at the interface between a cholesteric liquid crystal and an immiscible oil at which the helical order (pitch p) in the bulk conflicts with the orientation induced at the interface, stabilizing an ordered array of disclinations. For a weak anchoring strength W of the director field at the colloidal surface, this creates a template, favoring particle positions either on top of or midway between defect lines, depending on α=R/p. For small α, optical microscopy experiments confirm this picture, but for larger α no templating is seen.