Etiological factors of bloodstream infections in oncological patients, who was hospitalized at the National Institute of Maria Skłodowska-Curie - National Research Institute in Warsaw in 2020-2022.

Aim Of The Study: The purpose of the study was the microbiological analysis of bloodstream infections in patients hospitalized at the National Institute of Oncology, Maria Skłodowska-Curie - National Research Institute in the period from 01/01/2020 to 31/10/2022.

Material And Methods: In the period from 01/01/2020 to 31/10/2022, 18,420 blood cultures obtained from patients hospitalized at the NIO-PIB were analysed in the Department of Clinical Microbiology (total for the presence of bacteria and fungi). Culture for the presence of bacteria was carried out in the BactAlert automatic system by bioMerieux, and for fungi in the Bactec FX automatic system by Becton Dickinson.

Deepfakes and Democracy (Theory): How Synthetic Audio-Visual Media for Disinformation and Hate Speech Threaten Core Democratic Functions.

Observers fear that deepfakes will shake the very foundations of democracy. Notwithstanding, in-depth scholarly analyses of deepfakes' political impact are rare, and do not consider theories of democracy. This contribution helps close this research gap, drawing on Warren's problem-oriented democracy theory, as well as theories of deliberative democracy and contributions on the role of trust in democracies.

Small mutations in Duchenne/Becker muscular dystrophy in 164 unrelated Polish patients.

In the 164 patients with Duchenne/Becker muscular dystrophy, we found 142 different small mutations including 51 novel mutations not listed in the LOVD, the UMD-DMD, the ClinVar, and the HGMD databases. Among all mutations, nonsense mutations occurred in 45.7%, frameshift mutations in 32.

Perception of Old Age by the Inhabitants of Poland.

: People's self-esteem and public perception of senior citizens both play important roles in perceiving old age. The public perception manifests itself in adopting specific attitudes toward the elderly. : The work aimed at attempting to specify how adults and the elderly perceive old age.

Deletions, not duplications or small mutations, are the predominante new mutations in the dystrophin gene.

Examination of the carrier state was performed in 744 unrelated mothers of the Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) probands with identified mutations in the dystrophin gene. Owing to that it was possible to assess frequency and type of new mutations in the gene. Contrary to the Japanese observations of Lee et al.

Prenatal diagnosis of Duchenne and Becker muscular dystrophies: Underestimated problem of the secondary prevention of monogenetic disorders.

Aim: The aim of this study was to analyze the influence of effective preconceptional testing for carrier status in women at risk for Duchenne and Becker muscular dystrophies (D/BMD) on the prenatal diagnosis.

Methods: A retrospective analysis of 201 prenatal tests was performed in 169 Polish women at risk, in regard to time of testing for carrier status (prior to conception or during pregnancy) and carrier status of tested women, including confirmed D/BMD carriers (n = 78; 46.2%), D/BMD non-carriers - tested for germline mosaicism risk (n = 23; 13.

A rare subclinical or mild type of Becker muscular dystrophy caused by a single exon 48 deletion of the dystrophin gene.

In the material of 227 families with Becker muscular dystrophy (BMD), we found nine non-consanguineous families with 17 male individuals carrying a rare mutation-a single exon 48 deletion of the dystrophin gene-who were affected with a very mild or subclinical form of BMD. They were usually detected thanks to accidental findings of elevated serum creatine phosphokinase (sCPK). A thorough clinical analysis of the carriers, both children (12) and adults (5), revealed in some of them muscle hypotonia (10/17) and/or very mild muscle weakness (9/17), as well as decreased tendon reflexes (6/17).

Medical and Ethical Considerations Related to Viable Fetuses with Trisomy 13 in the 36th Week of Pregnancy--a Review of the Literature.

Patau syndrome was first described in 1960 as a group of birth defects caused by trisomy of chromosome 13 (T13). Providing accurate information and relevant reproductive genetic counseling that would allow parents to make informed decisions is not easily accomplished because of the limited information available prenatally. Only 1/3 of all cases of T13 are diagnosed prenatally, which means it cannot be expected that most cases will be detected early in pregnancy, that the parents will decide to terminate the pregnancy, and that difficulties will be avoided.

Biomarkers for risk stratification in secondary cardiovascular prevention. A role of red blood cell distribution width and calcium score.

Background: Patients with coronary artery disease (CAD) are considered as high risk in terms of secondary cardiovascular prevention. However, obviously the risk is not homogenous across the whole group. Red blood cell distribution width (RDW) has been recently related to adverse outcomes in patients with atherosclerosis.

First-trimester spontaneous pregnancy loss - molecular analysis using multiplex ligation-dependent probe amplification.

Spontaneous miscarriages are the most frequent complications of pregnancy and, in at least half of cases, are caused by chromosomal abnormalities, mainly aneuploidies. We present the preliminary results of the implementation of multiplex ligation-dependent probe amplification (MLPA) in the detection of chromosomal aberrations in the tissue derived from first-trimester miscarriage and evaluate the limitations and requirements of the method. We studied 181 MLPA analyses with subtelomeric and subcentromeric probe kits for all chromosomes (SALSA P070 and SALSA P181) performed on the first-trimester spontaneous miscarriage products in our Department of Genetics between September 2012 and December 2014.

[Etiology of infection associated with neoplastic changes of organs in the head and neck in patients hospitalized in the Oncology Centre in Warsaw].

Introductions: According to clinical observations primary neoplastic lesions in the head and neck are often complicated by infection. The incidence of postoperative complications of cancer lesions of the head and neck, oral cavity, upper airways or larynx is from 19% up to 47% cases but in extensive and long-term operations can reach 80%.

Methods: We retrospectively evaluated results of microbiological investigations of 312 clinical specimens collected from patients from Clinical Head and Neck Cancers of On- cology Center in Warsaw in the years 2008 -2012.

[The colonization of the digestive tract multidrug-resistant strains hospitalized patients in Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology].

Introduction: The aim of the study was a retrospective analysis of intestinal flora for the presence of multidrug-resistant strains, isolated from patients hospitalized in clinics Oncology Center from 01.01.2010 to 30.

On the origin of surface imposed anisotropic growth of salicylic and acetylsalicylic acids crystals during droplet evaporation.

In this paper droplet evaporative crystallization of salicylic acid (SA) and acetylsalicylic acid (ASA) crystals on different surfaces, such as glass, polyvinyl alcohol (PVA), and paraffin was studied. The obtained crystals were analyzed using powder X-ray diffraction (PXRD) technique. In order to better understand the effect of the surface on evaporative crystallization, crystals deposited on glass were scraped off.

Inability to have children caused by recurrent HELLP syndrome in early pregnancies - implications for a review of literature.

This review is inspired by a case of two pregnancies of the same patient complicated by HELLP syndrome, which suggests that there is a predisposition for the occurrence of preeclampsia and HELLP syndrome in early pregnancy. HELLP syndrome, uncommon below the 20th week and rarer still in two consecutive pregnancies, appeared in two pregnancies of the same woman. The aim of our work is to try to understand the cause of heterogeneity of HELLP syndrome and help find a way of prolonging such pregnancies.

Prosthetic reconstruction of broken canine teeth in dogs with use of cast metal posts.

Prosthodontic treatment, especially restorations of fractured teeth in small animals, has been the subject of many veterinary dental analyses in relation to techniques of endodontic treatment, preparation and cementation, as well as the general principles of prosthodontic treatment. The purpose of this paper is to present a previously undescribed method of all-in-one crown and root prosthetic restoration of fractured teeth in large dogs, together with a thorough analysis of the drawbacks, which may help veterinary dentists to use an evidence-based approach when deciding on the type of treatment for their patients with tooth fractures.

Initiation of preterm labor.

Preterm births are still a major problem in obstetrics. It is estimated that preterm births occur in about 12% of all pregnancies. Due to advances in medical technology and better care of fetuses and premature babies, the preterm mortality rate has been falling (as recently as 1995 the survival rate in the US for premature infants born at 34 weeks amounted to only a fraction of the corresponding rate for those born after 37 weeks).

Depression in women aged 75-89--predisposing factors and preventive measures.

Background: There are analyses showing the relationship between low and irregular physical activity and the risk of more frequent occurrences of depression symptoms in the future. There are studies that do not prove the connection between those two dependencies.

Objectives: The aim of this study was to find the relationship between physical activity before menopause and the occurrence of depression in senium.

[Fear-driven cesarean section on request].

Unlabelled: Traditionally, women gave birth surrounded by other, experienced women. Modern women not only require continuous support during labor, but they also want to have a part in decision-taking. That is why some of them, regardless of how much or how little medical knowledge they have, want to decide about the way of birth on their own.

HELLP syndrome in pregnancies below 26th week.

Objective: To test the hypothesis that HELLP syndrome may be more likely to develop earlier, if a pregnant woman has aPL antibodies, and to observe clinical and laboratory factors preceding the occurrence of HELLP syndrome.

Materials And Methods: The study consisted in retrospective analysis, with updated verification, of HELLP syndrome in pregnancies below 26th week in our clinic in the years 1992-2010.

Results: HELLP syndrome, if it occurred before the 26th week, occurred only in women with preeclampsia superimposed on chronic hypertension and in women with aPL antibodies.

[Socioeconomical status of life and regularity of intake of medicines among hypertensive patients].

Unlabelled: As hypertension occurs very commonly in contemporary population, its complications and costs of treatment are one of the most important health and social issues. Non-compliance of the patients with respect to the intake of medicines and not-obeying medical instructions on healthy life style are said to be an important cause of hypertension treatment failures. Socioeconomic status of life has also a strong impact on the regularity of medicine intake.

Nutrition habits of patients operated because of coronary heart disease: income structure linkage.

Purpose: The purpose of the above work is description and assessment of nutritional habits of the patient group operated because of CHD in relation to their income sources.

Material And Methods: Among 100 patients hospitalized in The Cardiosurgery Clinic of Pomeranian Medical University in Szczecin, (72 M and 28 F) there were collected data concerning nutritional habits and income sources. To estimate the way of nutrition there was used the method of a direct interview, led individually according to the questions of an anonymous questionnaire.

Mechanistic information on the copper-catalysed autoxidation of mercaptosuccinic acid in aqueous solution.

Copper(II) ions react rapidly with sulfur from thiol groups, forming two distinct, intensely absorbing, short-lived intermediates, which decompose in a subsequent redox reaction to produce reduced copper and disulfides. In this study we report the results of a mechanistic study on the reaction between mercaptosuccinic acid, HO(2)CCH(2)CH(SH)CO(2)H, and Cu(2+)(aq) and [Cu(tren)H(2)O](2+), tren = tris(2-aminoethyl)amine. Spectroscopic and kinetic data indicate that in the presence of an excess of thiol, at least two distinct complexes are formed, with very different decomposition rate constants and an absorption maximum at 346 nm.

Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.

Cysteine peptidases and their endogenous inhibitors (CPI) have been shown to be involved in tumor progression and metastasis. Since their activity has been found to be changed in tumor tissue and/or body fluids of cancer patients, the determination of the peptidase/inhibitor levels is considered as a procedure of diagnostic value. Determination of cathepsin B, its precursor and inhibitor activity in homogenates of tumors and control breast tissue samples of patients with invasive ductal and lobular breast carcinoma and with benign breast disease (BBD) was performed using fluorometric assay.