Publications by authors named "Pawel Szczepaniak"
Article Synopsis
- Bacteria can form diverse populations with different characteristics, which help them adapt to changing environments.
- Scientists studied E. coli under heat shock and found two types of subpopulations: a high-density (HD) group that grew well and a low-density (LD) group that grew slowly but showed more resilience to stress.
- The LD subpopulation had higher protein oxidation and fewer ribosomes compared to the HD group, suggesting that oxidative stress rather than protein aggregation played a key role in their growth limitations.
- This research highlights how heat stress can create distinct subpopulations in bacteria, impacting their survival and growth behaviors under various conditions.
Recent studies have revealed that antibiotics can promote the formation of reactive oxygen species which contribute to cell death. In this study, we report that five different antibiotics known to stimulate production of reactive oxygen species inhibited growth of Escherichia coli biofilm. We demonstrated that supression of biofilm formation was mainly a consequence of the increase in the extracellular concentration of indole, a signal molecule which suppresses growth of bacterial biofilm.
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