Publications by authors named "Pawel S Konieczny"
Article Synopsis
- The study explores how interactions between cancer cells and nearby fibroblasts lead to the activation of cancer-associated fibroblasts (CAFs), which are crucial for cancer development.
- By co-culturing prostate fibroblasts with either normal or cancerous prostate cells, researchers used mRNA sequencing to analyze changes in gene expression and transcription factor (TF) activity.
- Findings indicate that normal epithelial cells primarily trigger an inflammatory response in fibroblasts, while cancerous cells cause significant gene expression changes linked to cell transformation and motility through the dysregulation of 45 transcription factors and key signaling pathways.
Aims: Negative pressure wound therapy (NPWT) is commonly used in diabetic foot ulceration (DFU). The molecular mechanisms of NPWT action, particularly outside of the wound site, have not been described. We assessed NPWT's effect on circulating miRNA expression levels in type 2 diabetes (T2DM) patients with DFU.
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