A flail chest is one of the possible medical conditions suffered by individuals who were injured in traffic accidents, caused by multiple fractures of the ribs and sternum. Which often results in paradoxical chest movements. The consequence may be respiratory failure and need for long-term mechanical ventilation.
View Article and Find Full Text PDFInt J Environ Res Public Health
February 2022
Unlabelled: The pain experienced by paediatric patients is rarely evaluated in emergency departments. The aim of the present study was to compare the degree of conformity in patients' pain severity when assessed by themselves (if possible), their parents and a triage nurse trained in pain evaluation.
Methods: A cross-sectional observational study was conducted at a tertiary paediatric emergency department in Eastern Poland involving children (aged six months to eighteen years), their parents and nurses.
(1) Lung cancer (both small cell and non-small cell) is the leading cause of new deaths associated with cancers globally in men and women. Long noncoding RNAs (lncRNAs) are associated with tumorigenesis in different types of tumors, including lung cancer. Herein, we discuss: (1) An examination of the expression profile of lncCDH5-3:3 in non-small cell lung cancer (NSCLC), and an evaluation of its functional role in lung cancer development and progression using in vitro models; (2) A quantitative real-time polymerase chain reaction assay that confirms lncCDH5-3:3 expression in tumor samples resected from 20 NSCLC patients, and that shows its statistically higher expression levels at stage III NSCLC, compared to stages I and II.
View Article and Find Full Text PDFIntroduction: Air pollution is one of the most important issues of our times. Air quality assessment is based on the measurement of the concentration of substances formed during the combustion process and micro-particles suspended in the air in the form of an aerosol. Microscopic atmospheric particulate matters (PM) 2.
View Article and Find Full Text PDFImmunotherapy is a promising therapeutic option for patients with non-small cell lung cancer (NSCLC) who do not qualify for surgery. In patients with advanced NSCLC, systemic immune suppression is frequently observed, therefore, researchers are investigating the tumor microenvironment for less invasive and more effective methods of treating lung cancer. Monocytic myeloid-derived suppressor cells (Mo-MDSCs) are potent suppressors of tumor immunity; therefore, this population may significantly impede the application of immunotherapy to treat cancer.
View Article and Find Full Text PDFBackground: Healthy condition and chronic diseases may be associated with microbiota composition and its properties. The prevalence of respiratory haemophili with respect to their phenotypes including the ability to biofilm formation in patients with sarcoidosis was assayed.
Methods: Nasopharynx and sputum specimens were taken in 31 patients with sarcoidosis (average age 42.
Background: Haemophili are representative microbiota of the upper respiratory tract. The aim of this study was to assess the effects of perioperative antimicrobial prophylaxis and/or postoperative treatment on Haemophilus parainfluenzae prevalence, and antimicrobial sensitivity in short-term hospitalized patients with lung cancer who underwent surgery.
Results: Samples were collected from 30 short-term hospitalized patients with lung cancer and from 65 healthy people.
Introduction: Natural killer T (NKT) cells are involved in the antitumor response by direct cytotoxicity and indirectly through activation of effector cells. Recent studies have shown a relationship between the number and function of NKT cells and clinical outcomes. NKT cells seem to represent a promising tool for immunotherapy of cancer.
View Article and Find Full Text PDFMyasthenia gravis is an autoimmune disorder of peripheral nervous system, leading to fluctuating muscle weakness. It is caused by circulating antibodies that block acetylcholine nicotinic postsynaptic receptors at the postsynaptic neuromuscular junction. Myasthenic crisis is a life-threatening complication, which is defined as weakness from acquired myasthenia gravis.
View Article and Find Full Text PDFIntroduction: Despite the progress which has been made in the diagnosis and treatment of lung cancer, it is still one of the main causes of death in both men and women. The introduction of new therapeutic modalities did not improve the 5-year survival results of lung cancer patients. The Lublin Voivodeship is a sparsely-inhabited area with little urbanization and a population of about 2.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
November 2012
Objective: To identify the sociodemographic characteristics and risk factors associated with suspected foreign bodies in the ear, nose, throat, airway, and esophagus among Polish children.
Study Design: Case series with chart review. Setting Tertiary care medical center.
We discuss clinical symptoms and radiological findings of variable esophageal foreign bodies as well as therapeutic procedures in Caucasian pediatric patients. A retrospective study of 192 cases of suspected esophageal foreign bodies between 1998 and 2010 was conducted. Data were statistically analyzed by chi-square test.
View Article and Find Full Text PDFFolia Histochem Cytobiol
October 2011
Anaerobes comprise most of the endogenous oropharyngeal microflora, and can cause infections of airways in lung cancer patients who are at high risk for respiratory tract infections. The aim of this study was to determine the frequency and species diversity of anaerobes in specimens from the lower airways of lung cancer patients. Sensitivity of the isolates to conventional antimicrobial agents used in anaerobe therapy was assessed.
View Article and Find Full Text PDFThe collection of 146 Staphylococcus epidermidis strains isolated from the nasopharynx of lung cancer patients has been studied for the ability of slime secretion and biofilm formation using the Congo red agar (CRA) test and the microtiter plate (MtP) method, respectively. The prevalence of the icaAD and the aap genes was also analyzed. Some isolates (35.
View Article and Find Full Text PDFBackground: Microbial colonization of pleural drains during the postoperative period may be regarded as an important factor in infection development. The aim of this paper was to determine the frequency and risk factors associated with microbial colonization of pleural drains in patients with non-small-cell lung cancer (NSCLC) who underwent surgical resection.
Material/methods: A total of 72 pleural drain fluids obtained from 36 patients with NSCLC were microbiologically examined.
Extramedullary plasmacytomas, especially located in the thorax, are very rare. We present a 31-year-old patient who was diagnosed with a solitary plasmacytoma located in the lung mimicking a primary lung tumor. After several weeks, this developed into multiple myeloma.
View Article and Find Full Text PDFWe determined the frequency of colonization of nasopharynx by Gram-negative rods in 63 patients with lung cancer undergoing thoracic surgery who routinely receive antimicrobial prophylaxis. Throat and nasal specimens were taken from each patient twice: on the day of hospital admission (examination I) followed by thoracic surgery and on the fourth day after thoracic surgery (examination II). The isolated strains were identified using API 20E or API 20NE microtests.
View Article and Find Full Text PDFPolichloride vinyl (PCV) is a widely used thermoplastic polymer, also in the production of medical devices. In the present study we assess the influence of EDTA in vitro on the biofilm structure formed by Staphylococcus epidermidis isolates on PCV biomaterials (Nelaton and Thorax catheters). The 6 strains of S.
View Article and Find Full Text PDFDendritic cells (DCs) are the most potent antigen presenting cells, which can stimulate a cellular immune response against malignant tumor cells. Many authors have described the phenomenon of tumor infiltration by dendritic cells and emphasized an immunosuppressive tumor influence on DC function. In the present study, we examined the presence of myeloid CD1c+ (BDCA-1+) dendritic cells and lymphoid/plasmacytoid CD303+ (BDCA-2+) dendritic cells in peripheral blood, lymph nodes and cancer tissue of patients with non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFBackground: There have been a limited number of studies giving the incidence of pleural metastasis from female genital tract tumors.
Case: An unusual case occurred of recurrent pleural malignant effusion associated with disseminated serous papillary endometrial adenocarcinoma (EC). A total abdominal hysterectomy with bilateral salpingo-oophorectomy, pelvic lymphadenectomy, appendectomy and omentectomy was performed.
In the present study 48 patients with non-small cell lung cancer (NSCLC) were included--20 patients from control group and 28 patients after at least one course of preoperative chemotherapy. The analysis of nasopharyngeal microflora in these patients suggests that preoperative chemotherapy can be regarded as a predisposing factor for colonization of mucous membrane of throat with yeast-like fungi--Candida spp.
View Article and Find Full Text PDFAnn Univ Mariae Curie Sklodowska Med
November 2004
Unlabelled: The aim of the study was a retrospective analysis of effectiveness of surgical treatment of severe diffuse emphysema, including urgent cases with symptomatic pneumothorax. We analyzed 99 patients with severe diffuse emphysema who underwent surgical treatment in Department of Thoracic Surgery in Lublin between 1995 and 2001. The evaluated group consisted of 86 men and 13 women aged from 27 to 83 (mean age 56.
View Article and Find Full Text PDFCoagulase-negative staphylococci (CNS) represent an important group of etiologic agents of infections associated with plastic biomaterials, e.g. drains.
View Article and Find Full Text PDF