Publications by authors named "Pawel Poznanski"

Article Synopsis
  • - The study investigates how hemodialysis affects the oxygen-binding ability of hemoglobin (measured by p50) in patients with chronic kidney disease (CKD) and explores the relationship between p50 and various blood parameters.
  • - A total of 180 CKD patients were analyzed, dividing them into hemodialysis (HD) and non-hemodialysis (non-HD) groups, finding that HD patients required higher doses of erythropoietin but had similar hemoglobin levels compared to non-HD patients.
  • - Results indicated that non-HD patients experienced more severe metabolic acidosis and lower blood pH, while p50 values differed significantly between the two groups, suggesting a potential impact of dialysis on oxygen delivery
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is a cosmopolitan fungal pathogen that destroys cereal production, in terms of loss of yield and grain contamination with mycotoxins, worldwide. Chitosan is a natural biopolymer abundant in the environment with proven antifungal properties that also acts as a plant immunity elicitor. Despite a number of articles, there is a lack of systematic comparison of antifungal activity of diverse batches of chitosan.

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Chitosan (CS), a biopolymer derived from chitin, is known for strong antifungal activity while being biodegradable, biocompatible, and non-toxic. Because of its characteristic it has been widely used in control of fungal pathogens. Antifungal activity of chitosan can be further enhanced by obtaining chitosan nanoparticles (CSNPs).

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The popularity of living-donor organ donation has increased recently as an alternative to deceased-organ donation due to the growing need for organs and a shortage of deceased-donor organs. This procedure requires an in-depth health assessment of candidates, who must be in excellent physical and mental health. We present a potential living-kidney donor withdrawn from donation due to a newly diagnosed Paget's disease of bone (PDB).

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Global climate change and the urgency to transform crops require an exhaustive genetic evaluation. The large polyploid genomes of food crops, such as cereals, make it difficult to identify candidate genes with confirmed hereditary. Although genome-wide association studies (GWAS) have been proficient in identifying genetic variants that are associated with complex traits, the resolution of acquired heritability faces several significant bottlenecks such as incomplete detection of structural variants (SV), genetic heterogeneity, and/or locus heterogeneity.

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Global climate change and the urgency to transform food crops require substantial breeding efforts to meet the food security challenges. Barley, an important cereal, has remained a preferential host of phytotoxic diseases caused by the that not only severely reduces the crop yield but also compromises its food quality due to the accumulation of mycotoxins. To develop resistance against infections, a better understanding of the host-pathogen interaction is inevitable and could be tracked through molecular insights.

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Background: Molnupiravir demonstrated an in vitro antiviral activity against positive-sense RNA viruses, including SARS-CoV-2. The study aimed to present the results of outpatient molnupiravir use in kidney transplant recipients and hemodialysis patients during the first months of 2022 in Poland.

Methods: The retrospective observational cohort study at one kidney transplant center included 36 patients diagnosed with COVID-19 with an automated nucleic acid amplification test on nasopharyngeal swab specimens.

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Article Synopsis
  • The SARS-CoV-2 pandemic severely impacted both the psychological well-being and healthcare access for patients with chronic illnesses, complicating their medical needs and increasing their vulnerability to the virus.
  • A study involving 398 patients from various chronic conditions (like psoriasis and multiple sclerosis) found that nearly half of them showed significant signs of psychopathology, with the highest distress observed in patients with multiple sclerosis.
  • While factors like COVID-19 infections and quarantines did not significantly alter these psychological outcomes, the study emphasizes the need for more research to understand the full impact of the pandemic on chronically ill individuals' mental health.
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Article Synopsis
  • The COVID-19 pandemic, caused by the SARS-CoV-2 virus, elicits a strong immune response that can lead to severe systemic inflammation and cytokine release syndrome in critical cases.
  • The evolving SARS-CoV-2 variants challenge the immunity developed through previous infections or vaccinations, making immune response understanding crucial for managing the disease.
  • This paper reviews the mechanisms of immune responses to various COVID-19 vaccines and highlights specific considerations for different patient populations with altered immune systems, along with tools for studying immune responses to the virus.*
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Acute kidney injury (AKI) in kidney transplant recipients (KTRs) is a common, yet poorly investigated, complication of urinary tract infections (UTI) and urosepsis. A retrospective comparative analysis was performed, recruiting 101 KTRs with urosepsis, 100 KTRs with UTI, and 100 KTRs without history of UTI or sepsis. The incidences of AKI in the urosepsis and UTI groups were 75.

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Living donor kidney transplantation is a widely performed medical procedure. Living kidney donation requires an in-depth health assessment of candidates. The potential living kidney donor must remain healthy after kidney removal.

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Background: It is still unclear whether COVID-19 convalescent kidney transplant recipients (KTR) and hemodialysis (HD) patients can develop anti-SARS-CoV-2 adaptive immunity. The aim was to characterize and compare the immune response to the virus in HD patients and KTR.

Methods: The study included 26 HD patients and 54 KTR-both convalescent (14 HD, 25 KTR) and unexposed.

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The paper describes problems with the transplantation process during the COVID-19 pandemic. Transplantation procedures and programs have been impacted by COVID-19. The number of transplants has fallen noticeably.

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Background: Initially, there were no data on the safety of COVID-19 vaccines in lactating women. The aim of our study was to evaluate the immune response to COVID-19 vaccinations in breastfeeding women.

Methods: The study included 32 breastfeeding women who, regardless of the study, had decided to be vaccinated.

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Tortuosity of the carotid artery is usually an asymptomatic vascular abnormality and is discovered accidentally during cerebral angiography. These vascular changes may aggravate surgical procedures in the neck region. We described a technique of permanent catheter insertion in patients with renal graft failure in whom renal replacement therapy was necessary.

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Background: Renal function is usually described by the estimated glomerular filtration rate (eGFR). The standard method used for living kidney donor evaluation in our center is the 24-hour urine creatinine clearance (CrCl) and kidney morphology assessment with computed tomography (CT). The aim of the study was the analysis of the correlation of CrCl with 15 published eGFR formulas and morphologic CT parameters to choose the most accurate kidney function estimation method before and after donation.

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Background: The aim of the study was to assess bioavailability aspects of tacrolimus formulations during conversion from twice-daily (TAC BID) to once-daily (TAC OD) formulation in 89 stable kidney transplant recipients.

Materials And Methods: The study included 89 stable kidney transplant recipients transplanted between 1998 and 2008 (37 female, 52 male, aged 46.0 ± 12.

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Post-transplant lymphoproliferative disorder (PTLD) is serious life-threating complication of transplantation. The clinical picture differs from lymphomas observed in the general population, with different manifestation, histopathology, higher aggressiveness with involvement of sites beyond the primary lymph node, and poorer outcome. The objective of the study was to present nine cases of PTLD observed in our centre among the kidney transplant recipient population and discuss the results with up-to-date literature.

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Animal-based models used in biomedical sciences allow to perform research that, conducted on humans, would be highly problematic because of bioethical and technical issues. Contemporary researchers race can lead to abuse, hence the need for special law regulations regarding this subject. This necessity reflected both in the EU and Polish legislation, and is rooted in the philosophical and moral achievements of Europe.

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