New egzoluminal circular surgical stapler.

The study presents the design, prototype version and preliminary results of in vivo testing of the egzoluminal circular surgical stapler for "end-to-end" anastomosis of bowels after the resection, where staples are put outside the intestinal lumen, and walls of the intestinal tube directly contact the intestinal mucous membrane. The adopted idea of an "end-to-end" intestinal anastomosis as well as a strong need for a device that would be re-usable have determined its specific design. The device is characterised by a kinematic mode of operation, different from the operating mode of commonly used staplers, and hence by a specific combination of the individual components.

Mesenteric lymph node Tgammadelta cells induced by gastrectomy in mice suppress cell-mediated immune response in vitro via released TGF-beta.

We have shown previously that gastrectomy, but not laparotomy alone, severely impairs contact sensitivity responses in vivo and selectively alters cell trafficking in gut associated lymphatic tissue. Here, we investigate the immunological role of different subpopulations of mesenteric lymph node cells (MLNCs) in the inhibition of contact sensitivity as well as their suppressive mechanisms. Suppressive cells were isolated from the mesenteric lymph nodes of gastrectomized mice and were added to cultures of lymphocytes from mice immunized with trinitrophenyl-chloride.

[The influence of trauma on immunological response (the role of Tgammadelta+ lymphocytes)].

The influence of trauma, especially surgical operation on immunological response has not been clarified sufficiently. The authors discuss the influence of surgical trauma on humoral and cell mediated immune response and on phagocytosis as well. The role of Tgammadelta+ lymphocytes in immunological processes that occur after trauma have been also discussed.

[Immunological aspects of trauma].

Injury breaks anatomical barriers of the body and leads to cell and tissue destruction. In response to trauma, repair and defense mechanisms, involved in tissue repair, wound healing, and prevention of infection, are induced. The magnitude of the trauma-induced response depends on the patient's overall condition and the severity of the injury.