[Tularemia vaccine strain is a potential vector].

The immunological and genetic properties of Francisella tularensis vaccine strain are discussion with regard to its use to produce recombinant vaccines. This bacterium-based vector is supposed to be an excellent object for investigating the role of protective antigens in the development of immunity against intracellular bacteria.

[Role of glutathione containing amino acids in the correction of body's dysadaptation states].

Based on his own experimental findings and data available in the literature, the author provides evidence for the expediency of using glutamate alone and in combination with glycine and methionine to correct abnormalities accompanied by hypoxia and imbalance between the rate of free radical oxidation and the degree of antioxidative defense. Pathogenetic therapy with the adaptogens amino acids in combination with polycyclic aromatic hydrocarbons is considered.

[Impact of mycobacteria on nonspecific protective mechanisms associated with exchange of organic sulphur and nitrogen].

Guinea-pig experiments indicated that Mycobacteria tuberculosis (MBT) were actively involved in detoxification of the xenobiotics polycyclic aromatic hydrocarbons (PAH) and substantially altered the nonspecific protective mechanisms associated with activation of the body's antioxidative resources. MBT in the lung and liver tissues of animals long preexposed to PAH elevated the concentrations of sulphur-containing amino acids and glutathione with consumption of abundant nitrogen-rich adaptogenic antioxidants (arginine, urea) accumulated under the action of PAH. At the same time there is a upward trend for the body's antioxidative potentials both in a group infected with MBT and in group receiving PAH.

Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver.

17 beta-estradiol (E2) and progesterone (P) treatment of immature female rats (10 micrograms/100 g body weight) respectively resulted in 1.38-fold (p < 0.02) and 1.

[Means for the rational utilization of the bed resources under obligatory medical insurance].

Presents a multivariant system of rational use of the bed fund used in Samara Province [correction of district]. This system helped preserve the scope of hospital aid rendered to the population in 1993-1995 which was planned by the district program of obligatory medical insurance, despite cutting down about 5,000 beds in premises previously adjusted for therapeutic needs and old premises.

Cryptic plasmid pFNL10 from Francisella novicida-like F6168: the base of plasmid vectors for Francisella tularensis.

The plasmid pFNL1OO was created by ligation of Escherichia coli plasmid pBR328 and plasmid pFNL1O from Francisella novicida-like strain F6168. This plasmid was able to replicate and to express the genes for chloramphenicol and tetracycline resistance in both E. coli and F.

[The catabolism of polyamines].

The important role of the natural polyamines putrescine, spermidine and spermine in the normal and pathological cell growth is the main reason for the active investigation of their metabolism. The essential catabolic reactions of polyamine interconversion and terminal oxidation as well as data for the catabolic enzymes and the regulatory mechanisms of their activities are reviewed. The importance of catabolic reactions for the maintenance of the optimal polyamine concentrations during the cell growth and differentiation is also presented.

[Morphological features of tissue reactions in combined treatment of experimental tuberculosis induced by xenobiotics].

The trend to aggravated running and contribution of air pollution of large industrial centers with polycyclic aromatic hydrocarbons (PAH) to tuberculosis onset and progress dictate the necessity of the search for new treatment methods. The authors made an attempt to treat experimental tuberculosis with sodium glutamate and isoniazide under chronic exposure to PAH dust. Sodium glutamate especially in combination with isoniazide produces a good effect enhancing granulomatous reactions fibroplastic processes in the foci of specific inflammation.

[State of immunobiological reactivity of experimental animals to tuberculosis and exposure to coal tar].

Among most common environmental factors microflora and xenobiotics are capable of changing immunological resistance of human and animal body. Combined action of these factors on the animals has never been studied. Guinea pig experiments showed that M.

[Relationship of concentration -- time -- effect of benzol inhalation on the body in acute and subacute experiment].

Relationships between "concentration-time-effect" during inhalation exposure to benzol in acute and subacute experiments were determined. Experimental and theoretical data were in good correlation.

[Isolation and molecular-genetic characteristic of a cryptic plasmid from the Francisella novicida like F6168 strain].

A 4 Kb plasmid DNA has been isolated from Francisella novicida like strain F6168. Restriction map of the plasmid was constructed for restriction endonucleases HindIII, XbaI, EcoRV, BgIII. The plasmid pFN10 has been shown to be stably inherited by F.

[Rheum-orthopedics in the system of complex treatment of rheumatoid arthritis].

The author presents an original conceptual scheme of the complex medical rehabilitation of patients with RA on the basis of the conservative and surgical treatment of RA (3,000 cases). Successful results were attained in 70% of cases (follow-up of 5 years).

Distribution of polyamine oxidase activity in rat tissues and subcellular fractions.

The activity of polyamine oxidase (PAO) in rat tissues, and its subcellular distribution, were assayed using a simple polarographic method. The highest PAO activity was measured in the liver and the lowest in the skeletal muscle. In liver, kidney and uterus the highest specific PAO activity was found in the light mitochondrial fraction.

[The results of a mass psychoprophylactic examination using computers in a military unit].

84 patients who were wounded in Armenian earthquake (1988) have been examined. It was marked that all the purulent wounds of soft tissues of the extremities had been infected by bacterial associations. The most of them were resistant to penicillinum, tetracyclinum, laevomycetinum, kanamycinum, kefzol, keflin, and highly sensible to mezlocilinum, cyprofloksacinum, cefaperazonum and ceftazidimium.

[Health institutions under new economic mechanism and the development of insurance medicine].

A new economic mechanism provides for independence of health units, their financial independence and the possibility of developing specialized health care for the population of the territorial health complex. The necessity of preserving large health units within the newly developed regional public health infrastructure is stressed.