Dataset of human skin and fingernails images for non-invasive haemoglobin level assessment.

Anaemia, a decrease in total concentration of haemoglobin (Hb) in blood, affects substantial percentage of the population worldwide. Currently, the gold standard for determining the Hb level is the invasive analysis of venous blood. Yet, more and more research groups demonstrate the possibility of non-invasive Hb assessment using white light imaging of tissue sites where Hb is the main chromophore, in particular, fingernails.

[Maxillary sinusitis as a complication of dental implants placement: a case report].

The article presents a case of chronic odontogenic maxillary sinusitis and the results of its surgical treatment. The cause of the sinusitis, confirmed by the results of X-ray and pathohistological studies, was an inflammatory process affecting the bone tissue around the implant, installed in the place of the upper first molar which was accompanied by the development of an oroantral fistula. During the surgical intervention, the communication between the oral cavity and the maxillary sinus was eliminated, and the implant with the abutment, which was entirely in its cavity, was also removed.

Ceftobiprole for Treatment of Complicated Bacteremia.

Background: Ceftobiprole is a cephalosporin that may be effective for treating complicated bacteremia, including methicillin-resistant .

Methods: In this phase 3, double-blind, double-dummy, noninferiority trial, adults with complicated bacteremia were randomly assigned in a 1:1 ratio to receive ceftobiprole at a dose of 500 mg intravenously every 6 hours for 8 days and every 8 hours thereafter, or daptomycin at a dose of 6 to 10 mg per kilogram of body weight intravenously every 24 hours plus optional aztreonam (at the discretion of the trial-site investigators). The primary outcome, overall treatment success 70 days after randomization (defined as survival, bacteremia clearance, symptom improvement, no new bacteremia-related complications, and no receipt of other potentially effective antibiotics), with a noninferiority margin of 15%, was adjudicated by a data review committee whose members were unaware of the trial-group assignments.

[Endoscopic biopsy of a frontal lobe tumor infiltrating the lateral ventricle using intraoperative navigation].

The authors describe the clinical observation of a patient with a paraventricular tumor of the left frontal lobe and demonstrate the effectiveness of endoscopic biopsy of a volumetric mass of such localization through the lateral ventricle using intraoperative navigation. The disease manifested with convulsive seizures two years before the patient was admitted to the hospital. During this period of time, he was repeatedly examined.

The new generation double layered flow diverters for endovascular treatment of intracranial aneurysms: current status of ongoing clinical uses.

Introduction: The treatment of intracranial aneurysms has significantly evolved over the last decade with the advancement in endovascular techniques and devices. Flow diverters are the latest in the armamentarium for vascular reconstruction, aneurysm exclusion, and preservation of branch vessels. The possibility of treating various types of intracranial aneurysms, including those previously considered untreatable, has represented a new paradigm in the neurovascular era.

Relationship between aspirin use and subarachnoid hemorrhage: A systematic Review and meta-analysis.

Background: Aspirin has been associated with a decreasing risk of subarachnoid hemorrhage due to its anti-inflammatory mechanism of action and potential protective properties against aneurysm growth.

Objective: To determine the association between aneurysmal subarachnoid hemorrhage and aspirin use.

Methods: A systematic review of the literature and a meta-analysis were performed across the PubMed database.

MANAGEMENT OF EMOTIONAL DISORDERS IN ELDERLY PATIENTS UNDERGOING SURGICAL TREATMENT OF PROXIMAL FEMORAL FRACTURES.

The goal of our research was to study the to identify key aspects of the management of emotional disorders in the practice of operative treatment of proximal femoral fractures in elderly patients. The study was conducted with 24 patients who needed surgical treatment of proximal femoral fracture and were at risk for the development of psycho-emotional disorders due to the presence of emotional disorders of an anxiety-depressive nature were examined. The presence of such disorders was recorded at the time of admission, before and after surgical treatment using specialized psychodiagnostic techniques.

Will colleges survive the storm of declining enrollments? A computational model.

The approaching decline in the U.S. college-age population, sometimes referred to as a "demographic storm," has been identified as an existential threat to the future of American colleges and universities.

Deep brain stimulation as a possible treatment of hyperthermia in patients with serotonin syndrome.

Maintaining a body temperature within a narrow range is vital for the survival of all mammals, including humans. With the help of optogenetics, a better understanding of the thermoregulatory organs and pathways is achieved. Optogenetic activation of the GABAergic neurons in the ventral part of the lateral preoptic nucleus (VLPO) leads to decrease in the body temperature.

A possible novel technique for intraoperative imaging of the vertebral artery during arthrodesis of the upper cervical spine.

In elderly, the fractures in C1-C2 are a common entity. Poor bone quality and wide range of motion hamper the natural bone fusion, thus making surgery often the only possible way to deal with the underlying pathology. The proximity to important neurovascular structures represents the stabilization in this segment a challenge to the surgical team.

Rapid evacuation of chronic subdural hematoma - A possible traumatic brain injury (TBI).

The chronic subdural hematoma is an entity, which affects mainly the elderly patients. According to literature, the complication rate was up to 22,7%, including recurrence of hematoma, worsening of the neurological status, postoperative delirium, etc. Treating of a chronic subdural hematoma could be conservative and operative, including twist drill craniostomy, single or multiple burr hole drainage, and craniotomy.

Two patterns of cytokine production by placental macrophages.

Introduction: Macrophages participate in the regulation immune and morphogenetic events in the placenta. However, these roles remain unclear for placental macrophages (Hofbauer cells). The aims of this study were to characterize the consecutive steps of cytokine production (intracellular synthesis and secretion) in placental macrophages in early and late gestation and to compare the secretory profiles of placental macrophages and villous tissue.

[The Effect of Life-Style and Occupational Hazards on Development of Hysteromyoma].

The prospective observation of women with uterus myoma being on operative treatment in gynecological department of the Tula oblast clinical hospital during 2011-2012 was implemented. The regular female donors of the department of transfusiology of the given medical institution were used as the comparison group. It is established that female contingent with uterus myoma has a complex of such predisposing medical social risk factors as lower motion activity, financial neediness, increased stress load, diet of lower quality and its limitations, increased liquid intake, inobservance of work and rest regime, with passive character of longer day rest, certain occupational hazards.

Macrophages are a source of IL-17 in the human placenta.

Problem: To determine if placental macrophages (Hofbauer cells) can synthesize and secrete cytokines of the IL-17 family throughout pregnancy and to reveal the patterns of cytokine expression in early and late gestation.

Methods Of Study: Macrophages were isolated from the first-trimester and term placental villous tissues from normal pregnancies. Basal and stimulated intracellular production of IL-17A, IL-17E, IL-17F as well as IL-17A secretion was quantified by flow cytometry and cytometric bead array, respectively.

Coordinated expression of TNFα- and VEGF-mediated signaling components by placental macrophages in early and late pregnancy.

Introduction: Mononuclear phagocytes are thought to significantly contribute to cytokine regulation at the maternal-foetal interface, but the role of placental macrophages has been poorly investigated. TNFα and VEGF were demonstrated to have regulatory effects on basic structures of the placenta, particularly the trophoblast and blood vessels. The aims of this study were to determine the expression of TNFα, VEGF and related receptors in placental macrophages, and how does the participation of placental macrophages alter with gestational age in TNFα- and VEGF-mediated signaling.

Comparative phenotypic characterization of human cord blood monocytes and placental macrophages at term.

The expression of surface molecules in cord blood monocytes and placental macrophages was studied using flow cytometry. When compared with monocytes, macrophages presented a decrease in HLA-DR and LAP/TGF-β1 levels and increased expression of alternative activation markers, especially CD206. No difference in the production of the apoptotic factors TRAIL and TWEAK was observed, whereas the levels of cytokine receptors in monocytes were significantly higher than in macrophages.

In vitro expression of vascular endothelial growth factor and its receptors by placental macrophages.

The expression of VEGF and membrane-bound and soluble forms of the VEGF-R1 receptor in cultured placental macrophages (trimesters I and III of pregnancy) was studied by flow cytometry, cytometric bead array, and ELISA. Nearly all population of placental macrophages (98%) was capable of producing VEGF during the early and late gestational periods. However, the expression of cellular VEGF-R1 varied from 3.

[Embolization of cerebral aneurysms in acute period of hemorrhage complicated by the development of vasospasm].

Results of endovascular treatment of cerebral aneurysms in acute period of hemorrhage complicated by the development of vasospasm in 80 patients were analyzed. The results of treatment of patients with vasospasm were worse. The appearance of vasospasm did not depend of the severity of the patient's state, so all the patients independent on their state need prophylactic measures against this complication.

IL-11 expression in human term placental macrophages.

Problem: IL-11 is a cytokine with pleiotropic activities, including gestational effects. Whereas IL-11 production by maternal reproductive tissues is extensively studied, there is poor information about IL-11 sources in the fetal counterpart of the maternal-fetal unit.

Method Of Study: We investigated the expression of IL-11 in the purified human term placenta macrophages, using flow cytometry and immunoenzyme assay.

[The laser chromoendoscopy eradication of Helicobacter pylori].

35 patients with absence of positive dynamics after course of treatment of diseases associated with Helicobacter pylori infection and without achievement of eradication are surveyed. The original technique of Helicobacter pylori endoscopy eradication with use of the therapeutic laser in length of a wave of 660 nanometers is offered. Carrying out of rate laser chromoendoscopy eradication considerably reduces terms of healing of inflammatory-destructive changes of stomach and duodenum mucous membrane allows achieving of Helicobacter pylori eradication.

[Results of endoscopic inspection of upper digestive tract of IHD patients].

Comparative studying results of esophagogastroduodenoscopy by 150 ischemic heart disease patients and 50 patients who are passing preventive inspection are lead. Performance of endoscopic reveals researches pathognomonic for ischemic heart disease of change of stomach and duodenum mucous membrane, testifying about presence of chronic inflammatory-destructive process.

[Correlation of morphologic and humoral indicators in Helicobacter infections].

50 patients without gastroduodenal and somatic pathology and considering healthy are surveyed. Carrying out of the correlation analysis of results of morphological research of biopsies of stomach and duodenum mucous and laboratory parameters of peripheral blood has revealed that progressing of infection H. pylori leads to strengthening immunoinflammatory to reaction in system blood-groove.

[Effect of aktovegin on dynamics of the oxygen methabolism in tissues].

The analysis of aktovegin impact on methabolism dynamics of oxygen in tissues was performed. Indirect impact of aktovegin on the oxygen cascade dynamics is provided through the mechanism of the erythrocytes saturation by oxygen. The efficacy of aktovegin application as antihypoxic preparation in patients with an acute gastric strees-affection was proved.

[Minimally invasive surgery of patients with hypertensive intracerebral bleedings].

An analysis of results of surgical treatment of 79 patients aged from 41 to 72 years with hypertensive intracerebral hematomas of supratentorial localization has shown that results of surgical treatment depended on the severity of the patients' state, the degree of impairment of consciousness, volume and localization of hematoma, ventricular hemorrhage and in less degree on the terms of operation and the degree of displacement of the median structures of the brain. The endoscopic techniques proved to be preferential in hematomas of the lateral and mixed localizations with the volume not more than 60 cm3. The developed method using a cannula allowed abandon open operations in most patients with the lateral and mixed hematomas.