Publications by authors named "Pavlos Lykoudis"
Article Synopsis
- The study looked at how diabetes affects patients with pancreatic cancer who had surgery to remove part of their pancreas.
- They found that having diabetes didn't change the chances of surviving for five years or the chances of cancer coming back after surgery.
- So, doctors can treat diabetic patients the same as those without diabetes when considering surgery.
Article Synopsis
- Patients undergoing pancreaticoduodenectomy for distal cholangiocarcinoma (dCCA) have a high recurrence rate, with 65% developing recurrence mostly within three years post-surgery.
- The study identified common recurrence patterns, including local, distant, and mixed types, with primary sites being the pancreatic bed, liver, and lungs.
- Key predictive factors for recurrence included cancer stage, type of surgical resection, and various histological features, helping inform potential follow-up treatments or strategies.
Backgrounds/aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes.
View Article and Find Full Text PDFBackground: Pancreatoduodenectomy (PD) is associated with significant postoperative morbidity. Surgeons should have a sound understanding of the potential complications for consenting and benchmarking purposes. Furthermore, preoperative identification of high-risk patients can guide patient selection and potentially allow for targeted prehabilitation and/or individualized treatment regimens.
View Article and Find Full Text PDFDoes an extensive diagnostic workup for upfront resectable pancreatic cancer result in a delay which affects survival? Results from an international multicentre study.
Ann Hepatobiliary Pancreat Surg
November 2023
Backgrounds/aims: Pancreatoduodenectomy (PD) is recommended in fit patients with a carcinoma (PDAC) of the pancreatic head, and a delayed resection may affect survival. This study aimed to correlate the time from staging to PD with long-term survival, and study the impact of preoperative investigations (if any) on the timing of surgery.
Methods: Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD outcomes.
Introduction: Adjuvant chemotherapy (AC) can prolong overall survival (OS) after pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). However, fitness for AC may be influenced by postoperative recovery. We aimed to investigate if serious (Clavien-Dindo grade ≥ IIIa) postoperative complications affected AC rates, disease recurrence and OS.
View Article and Find Full Text PDFArticle Synopsis
- The study examined outcomes of pancreatoduodenectomy (PD) in patients with resectable ampullary adenocarcinoma, focusing on factors influencing five-year recurrence and survival rates.* -
- In the analysis of 394 patients, the five-year survival rate was found to be 54%, with 45% experiencing recurrence, typically within 14 months, and common recurrence sites including the liver and lymph nodes.* -
- Key predictors of increased recurrence and lower survival included factors like lymphatic invasion, positive resection margins, and specific histological characteristics, suggesting that patients with these features may benefit from additional adjuvant therapy.*
Background: Ovarian cancer is the leading cause of death from gynecological cancer in the UK. The standard of care is a combination of surgery and chemotherapy. The aim of the treatment is the resection of all macroscopic disease.
View Article and Find Full Text PDFIntroduction: The SARS-CoV-2 pandemic presented healthcare providers with an extreme challenge to provide cancer services. The impact upon the diagnostic and treatment capacity to treat pancreatic cancer is unclear. This study aimed to identify national variation in treatment pathways during the pandemic.
View Article and Find Full Text PDFVenous and arterial thromboembolism are both serious extraintestinal manifestations of inflammatory bowel disease (IBD). Acquired risk factors seem to play a more prominent role than congenital in promoting thrombotic events. Prevention of thromboembolism is thus mainly aimed at minimizing the acquired/reversible risk factors (e.
View Article and Find Full Text PDFBackground: Expansion of laparoscopic major hepatectomy is still limited mainly due to the well-recognised technical difficulties compared to open surgery, and doubts regarding the oncological efficiency when major resections are required.
Methods: Patients undergoing open right hepatectomy (ORH) were matched with patients undergoing laparoscopic right hepatectomy (LRH) and compared for perioperative outcomes.
Results: Seventy patients were included: 36 patients underwent LRH and 34 ORH.
Introduction: The aims of our study were to evaluate the impact of increased intra-abdominal pressure (IAP) on central nervous system (CNS) cytokines (Interleukin 6 and tumor necrosis factor), lactate and perfusion pressures, testing the hypothesis that intra-abdominal hypertension (IAH) may possibly lead to CNS ischemia.
Methods: Fifteen pigs were studied. Helium pneumoperitoneum was established and IAP was increased initially at 20 mmHg and subsequently at 45 mmHg, which was finally followed by abdominal desufflation.