Stability of Frequent Exacerbator Phenotype in Patients with Chronic Obstructive Pulmonary Disease.

Background: At present, there is little information in Bulgaria regarding the rate and stability of frequent-exacerbation phenotype in COPD patients.

Aim: To study the rate and stability of frequent-exacerbation phenotype in COPD patients.

Materials And Methods: We followed up 465 COPD patients for exacerbations over a 3-year period.

Impact of thrombophilic genetic factors on pulmonary embolism: early onset and recurrent incidences.

The importance of genetic thrombophilic factors in the development of venous thromboembolism has been increasingly recognized. Factor V Leiden (FVL), prothrombin gene mutation G20210A (FII G20210), genetic variant C677T of the methylentetrahydrofolate reductase (MTHFR), as well as the polymorphism A2 (PlA2) in platelet glycoprotein IIb/IIIa were recently discussed. We analyzed the contribution of genetic thrombophilic factors to the pathogenesis of pulmonary embolism (PE) and their association with the early onset and recurrence of PE using DNA analysis methods.