Cyclophilin A as a Pro-Inflammatory Factor Exhibits Embryotoxic and Teratogenic Effects during Fetal Organogenesis.

The precise balance of Th1, Th2, and Th17 cytokines is a key factor in successful pregnancy and normal embryonic development. However, to date, not all humoral factors that regulate and influence physiological pregnancy have been completely studied. Our data here pointed out cyclophilin A (CypA) as the adverse pro-inflammatory factor negatively affecting fetal development and associated with pregnancy complications.

War in Ukraine and dialysis treatment: human suffering and organizational challenges.

In January 2021, there were 9648 patients in Ukraine on kidney replacement therapy, including 8717 on extracorporeal therapies and 931 on peritoneal dialysis. On 24 February 2022, foreign troops entered the territory of Ukraine. Before the war, the Fresenius Medical Care dialysis network in Ukraine operated three medical centres.

[Diagnostic errors in patients with giant-cell tumor, bone cyst and osteosarcoma].

The article contains diagnostic error analysis of 439 patients with giant-cell tumor (176), bone cyst (158) and osteosarcoma (105) aged 4-75 for theperiod of 1990-2015. Morphological investigation of surgical material taken from the pathological focus sowed that diagnostic errors in clinical and X-ray examinations comprised up to 40.6% in giant -cell cases, 37.

[The impact of the long-term exposure of industrial aerosols on clinical and functional indices of the broncho-pulmonary system in aluminum smelter workers].

It was found that the appearance of respiratory diseases among workers was established to be associated with the impact of aerosols with the complex chemical composition, exceeding corresponding MAC. Among respiratory diseases in workers there were detected predominantly chronic non-obstructive bronchitis - 59.15%, and chronic obstructive pulmonary disease (COPD) - in 35.

[Combined pathology of the upper gastrointestinal tract in children: current trends].

The article presents the current views and controversial issues problems comorbidity upper gastrointestinal tract in children and adolescents (gastroesophageal reflux disease and gastroduodenal diseases). Analyzed their own long-term observations, depending on the type of disease, severity of motor disorders, endoscopic and morphological picture, infection Helicobacter pylori. The possible options for the formation of gastroesophageal reflux disease in children and adolescents with gastroduodenal diseases.

[Assessment of microscopic state of stomach mucous membrane in children with functional dyspepsia].

The results of morphological research of stomach's mucouse membrane in children with functional dyspepsia are presented in the article. Microscopic changes were found in all examined children regardless of endoscopic state of the gastric and duodenum mucosa. Microscopic picture of the epithelium damage and regeneration was revealed; in more complicated cases, under the decline of regeneration potential features of interstitial inflammation appear.

[The operational characteristics of modes of differential diagnostic of benign and malignant neoplasms of skeletal system].

The article presents the operational characteristics of serological methods (neopterin, tumor necrosis factor-alpha, interleukin-6, molecules of adhesion of vascular endothelium, molecules of inter-cellular molecules of adhesion) of differential diagnostic of benign and malignant neoplasms of skeletal system. The differentiation of neoplasms occurs in a most successful way under analysis of complex of serological indicators.

A novel family of (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids - analogues of α-amino acids.

A series of novel (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids - analogues of proteinogenic and nonproteinogenic α-amino acids were prepared. The synthetic methodology was based on nucleophilic addition of (trifluoromethyl)phosphinic acid or (difluoromethyl)phosphinic acid or its ethyl ester to substrates with C=N or activated C=C double bonds. Analogues of glycine, phenylglycine, alanine, valine, proline, aminomalonic and aspartic acids were thus prepared.

Direct k-space mapping of the electronic structure in an oxide-oxide interface.

The interface between LaAlO(3) and SrTiO(3) hosts a two-dimensional electron system of itinerant carriers, although both oxides are band insulators. Interface ferromagnetism coexisting with superconductivity has been found and attributed to local moments. Experimentally, it has been established that Ti 3d electrons are confined to the interface.

[Long-term storage of industrial microbial strains].

Morphofunctional characteristics of industrial microorganisms belonging to different genera, species, and strains were investigated after 15 to 20 years of storage in liquid nitrogen. The taxonomic position of microorganisms, the cell physiological state prior to storage, and the cryoconservation regime were found to affect microbial cryoresistance. Protective media, density of cell suspensions, freezing rate, and heating temperature are the parameters important for development of efficient technologies for cryoconservation of industrial microorganisms at -196 degrees C.

CO-activator model for reconstructing Pt(100) surfaces: local microstructures and chemical turbulence.

We present the results of the modeling of CO adsorption and catalytic CO oxidation on inhomogeneous Pt(100) surfaces which contain structurally different areas. These areas are formed during the CO-induced transition from a reconstructed phase with hexagonal geometry of the overlayer to a bulklike (1 x 1) phase with square atomic arrangement. In the present approach, the surface transition is explained in terms of nonequilibrium bistable behavior.

Interface controlled electronic charge inhomogeneities in correlated heterostructures.

For heterostructures of ultrathin, strongly correlated copper-oxide films and dielectric perovskite layers, we predict inhomogeneous electronic interface states. Our study is based on an extended Hubbard model for the cuprate film. The interface is implemented by a coupling to the electron and phonon degrees of freedom of the dielectric oxide layer.

[Species-specific detection of Proteus vulgaris and Proteus mirabilis by the polymerase chain reaction].

Sets of primers for the species-specific detection of P. mirabilis and P. vulgaris by the polymerase chain reaction (PCR) were developed.

Critical behavior in an atomistic model for a bistable surface reaction: CO oxidation with rapid CO diffusion.

We analyze critical behavior associated with the loss of bistability for an atomistic model for CO oxidation on surfaces in the limit of infinite diffusion of CO. The model includes infinite nearest-neighbor repulsions between adsorbed immobile O. We use a "hybrid" treatment incorporating a lattice-gas description of the O adlayer, but tracking just the number of adsorbed CO (which are randomly distributed on non-O sites).

[Phagocytic activity of mouse peritoneal macrophages under administration of bacterial vaccines and prospidin].

Phagocytic activity of peritoneal macrophages in cases of separate and combined injections of killed bacterial vaccines and prospidin has been studied in the work. As a result of researches conducted, it has been found out that the injection of vaccines together with prospidin makes it possible to reduce an inhibiting effect of prospidin on phagocytic activity of monocyte-macrophagal cells; first of all it concerns their digestive activity. Thus, the immunodepressing effect of antiblastome drugs may be reduced with the help of injection of killed bacterial vaccines which stimulate nonspecific factors of organism protection, including antineoplastic ones.

[Biomimetic oxidation of benzene by a polynuclear manganese complex [Mn12O12(CH3CO2)16(H2O)4] under mild conditions].

The possibility of monooxygenase enzymes biomimetic construction models with the use of polynuclear manganese complexes was shown. It was demonstration that benzene is oxidized by polynuclear manganese complex [Mn12O12(CH3CO2)16(H2O)4] in acetonitrile solution at room temperature and atmospheric pressure yielding phenol with the selectivity more than 80%. It was determined that the addition of air oxygen as the reoxidizer to the reaction mixture didn't transfer the reaction into the catalytic mode.

Catalytic CO oxidation on nanoscale Pt facets: effect of interfacet CO diffusion on bifurcation and fluctuation behavior.

We present lattice-gas modeling of the steady-state behavior in CO oxidation on the facets of nanoscale metal clusters, with coupling via interfacet CO diffusion. The model incorporates the key aspects of the reaction process, such as rapid CO mobility within each facet and strong nearest-neighbor repulsion between adsorbed O. The former justifies our use of a "hybrid" simulation approach treating the CO coverage as a mean-field parameter.

[Breaking of distractors of the Harrington type after surgical treatment of scoliosis].

180 patients with scoliosis (aged 12-29 years) were subjected to the correction of deformation by means of the Harringtone type distractors and spondylodesis with utilization of osseous transplants. In 24 of them (13,3%) the distractor has been broken in different terms after the operation. The danger of the break increases with the age of the patients and abruptly increases in case of scoliosis of the V degree (in excess of 90 degrees) and in case of necessity to bend the distractor to correct the kyphoscoliosis.