Publications by authors named "Pavle Josipovic"
Article Synopsis
- - The study investigates how Fas-associated protein with death domain (FADD) influences different ways cells die after exposure to narrow-band UVB (NB-UVB) radiation, which can cause skin damage.
- - Researchers used specific cell death inhibitors and FADD-deficient mouse embryonic fibroblasts to explore the role of FADD, finding that without it, cells were more likely to undergo apoptosis due to reactive oxygen species (ROS).
- - Results show that while FADD-deficient cells promoted a type of cell death linked to autophagy, wild type cells engaged an intrinsic apoptotic pathway that was resistant to certain inhibitors, suggesting that FADD protects against excessive apoptosis during UV exposure.
Aim: Determine the levels of expression of pluripotency genes OCT-4 and SOX-2 before and after osteogenic differentiation of human mesenchymal stem cells (hMSCs).
Methods: Human MSCs were derived from the bone marrow and differentiated into osteoblasts. The analyses were performed on days 0 and 14 of the cell culture.
Unlabelled: Several studies have demonstrated that hematopoietic cells originate from endotheliumin early development; however, the phenotypic progression of progenitor cells during human embryonic hemogenesis is not well described. Here, we define the developmental hierarchy among intermediate populations of hematopoietic progenitor cells (HPCs) derived from human embryonic stem cells (hESCs). We genetically modified hESCs to specifically demarcate acquisition of vascular (VE-cadherin) and hematopoietic (CD41a) cell fate and used this dual-reporting transgenic hESC line to observe endothelial to hematopoietic transition by real-time confocal microscopy.
View Article and Find Full Text PDF[Cytotoxicity of polyphenolic/flavonoid compounds in a leukaemia cell culture].
Arh Hig Rada Toksikol
December 2008
Flavonoid components of propolis are biologically active substances with antioxidative, immunostimulative, immunomodulative, and anti-inflamatory properties. The aim of the study was to investigate their cytotoxic effect on different leukaemia cell lines. For this purpose we used five different flavonoids (quercetin, caffeic acid, chrysin, naringenin, and naringin) and five types of leukemia cell lines (MOLT, JURKAT, HL-60, RAJI and U937).
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