Publications by authors named "Pavithra Umashankar"
Filamentous fungi as emerging cell factories for the production of aromatic compounds.
Fungal Biol Biotechnol
November 2024
Microbial production of aromatic compounds from renewable feedstocks has gained increasing interest as a means towards sustainable production of chemicals. The potential of filamentous fungi for production of aromatic compounds has nonetheless not yet been widely exploited. Notably, many filamentous fungi can naturally break down lignin and metabolize lignin-derived aromatic compounds.
View Article and Find Full Text PDFThe dengue virus is a single-stranded, positive-sense RNA virus that infects ~400 million people worldwide. Currently, there are no approved antivirals available. CRISPR-based screening methods have greatly accelerated the discovery of host factors that are essential for DENV infection and that can be targeted in host-directed antiviral interventions.
View Article and Find Full Text PDFArticle Synopsis
- Small viral genomes lead to disorder in proteins, necessitating interactions with various binding partners for infection and pathogenicity.
- A segment of the flaviviral capsid protein, known as a molecular recognition feature (MoRF), changes from disordered to ordered when binding to proteins, highlighting its role in such interactions.
- Studies reveal that despite diverse sequences, MoRFs across flaviviruses show conserved interactions with host proteins, influencing processes like ribosome biogenesis and affecting disease progression and immune suppression.