Publications by authors named "Pavel Senyushkin"
Article Synopsis
- Advanced in vitro diagnostic technologies are essential for early disease detection and monitoring, and this study presents a new multiplex protein biosensing approach using self-assembling multi-material heterochains for improved sensitivity and accuracy compared to traditional methods like ELISA.
- The engineered biosensor utilizes semiconductor nanoparticles and polymer chains to generate strong optical signals that can effectively detect multiple protein biomarkers in a single test, achieving an ultra-low detection limit of 1 pg/mL.
- By incorporating a neural network algorithm, this biosensing technology enables rapid and high-throughput quantification of protein levels from various clinical samples, demonstrating its potential for next-generation diagnostic applications in healthcare.
Rapid detection of various exosomes is of great significance in early diagnosis and postoperative monitoring of cancers. Here, a divisional optical biochip is reported for multiplex exosome analysis via combining the self-assembly of nanochains and precise surface patterning. Arising from resonance-induced near-field enhancement, the nanochains show distinct color changes after capturing target exosomes for direct visual detection.
View Article and Find Full Text PDFBiomolecular markers, particularly circulating microRNAs (miRNAs) play an important role in diagnosis, monitoring, and therapeutic intervention of cancers. However, existing detection strategies remain intricate, laborious, and far from being developed for point-of-care testing. Here, we report a portable colorimetric sensor that utilizes the hetero-assembly of nanostructures driven by base pairing and recognition for direct detection of miRNAs.
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