Publications by authors named "Pavel Ryazanov"
In the current work, we aimed to evaluate the association of clinical data of Cushing's disease (CD) patients with mutation status and to study USP8-related molecular mechanisms connected to the regulation of corticotropinoma growth and activity. 35 CD patients were enrolled; the sequencing of exon 14 in revealed variants in eighteen adenomas, two of which were described for the first time in CD. variants were more common in women (94% vs.
View Article and Find Full Text PDFBackground: Parathyroid tumors are classified as parathyroid neuroendocrine neoplasia (NEN) by the IARC-WHO classification. These tumors can occur with NENs from other sites, which often require total-body [68Ga]-DOTA-peptides PET/CT. This study aimed to assess the utility of [68Ga]-DOTA-peptide PET/CT in imaging parathyroid NENs and to evaluate the underlying mechanisms.
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- This study investigates the genetic underpinnings of neuroendocrine tumors (NETs) by using targeted gene panels (TGPs) to identify novel genetic variants in a group of 93 patients with different NET subtypes.
- Out of the identified variants, some were already known to be linked to specific tumor types, while others were new associations that had not been previously recognized in the context of NETs.
- The research highlights the potential of TGPs to uncover previously unknown genetic factors in NET development, suggesting the need for further studies with larger samples to confirm these findings.
Persistent and recurrent hypercortisolism after transsphenoidal endoscopic surgery (TSS) is considered to be an urgent issue prompting the search for Cushing's disease (CD) remission predictors. The goal was to find a combination of predictors that can forecast the remission of CD after TSS. A total of 101 patients with CD who had undergone TSS were included.
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