Renal cell carcinoma in a transplanted kidney: a retrospective evaluation.

Introduction: Kidney transplantation is the optimal treatment modality for patients with end-stage chronic kidney disease. The long-term mortality of kidney recipients is 48-82% lower than that of patients on the waiting list. However, the risk of developing malignancies in these patients is twice as high as in the healthy population.

Single-Stage Microfluidic Synthesis Route for BaGdF:Tb-Based Nanocomposite Materials: Synthesis, Characterization and Biodistribution.

Rare-earth-doped nanoscaled BaGdF is known as an efficient contrasting agent for X-ray micro-CT and NMR as well as a promising candidate for X-ray photodynamic therapy, thereby opening an opportunity for theragnostic applications. Conventional synthesis of Ln-doped BaGdF consider a long-lasting batch procedure, while a conjugation with photosensitizer usually implies a separate stage requiring active mixing. To the best of our knowledge, in this work, we for the first time obtain BaGdF:Tb nanophosphors in a microfluidic route at temperatures as low as 100 °C while decreasing the time of thermal treatment down to 6 min.

Doxorubicin-Loaded Core-Shell UiO-66@SiO Metal-Organic Frameworks for Targeted Cellular Uptake and Cancer Treatment.

Beneficial features of biocompatible high-capacity UiO-66 nanoparticles, mesoporous SiO, and folate-conjugated pluronic F127 were combined to prepare the core-shell UiO-66@SiO/F127-FA drug delivery carrier for targeted cellular uptake in cancer treatment. UiO-66 and UiO-66-NH nanoparticles with a narrow size and shape distribution were used to form a series of core-shell MOF@SiO structures. The duration of silanization was varied to change the thickness of the SiO shell, revealing a nonlinear dependence that was attributed to silicon penetration into the porous MOF structure.

Candidate Tidal Disruption Event AT2019fdr Coincident with a High-Energy Neutrino.

The origins of the high-energy cosmic neutrino flux remain largely unknown. Recently, one high-energy neutrino was associated with a tidal disruption event (TDE). Here we present AT2019fdr, an exceptionally luminous TDE candidate, coincident with another high-energy neutrino.

Operando Photo-Electrochemical Catalysts Synchrotron Studies.

The attempts to develop efficient methods of solar energy conversion into chemical fuel are ongoing amid climate changes associated with global warming. Photo-electrocatalytic (PEC) water splitting and CO reduction reactions show high potential to tackle this challenge. However, the development of economically feasible solutions of PEC solar energy conversion requires novel efficient and stable earth-abundant nanostructured materials.

Synthesis, Characterization and Biodistribution of GdF:Tb@RB Nanocomposites.

Herein we report the development of a nanocomposite for X-ray-induced photodynamic therapy (X-PDT) and computed tomography (CT) based on PEG-capped GdF:Tb scintillating nanoparticles conjugated with Rose Bengal photosensitizer via electrostatic interactions. Scintillating GdF:Tb nanoparticles were synthesized by a facile and cost-effective wet chemical precipitation method. All synthesized nanoparticles had an elongated "spindle-like" clustered morphology with an orthorhombic structure.

Loading of the Model Amino Acid Leucine in UiO-66 and UiO-66-NH: Optimization of Metal-Organic Framework Carriers and Evaluation of Host-Guest Interactions.

Two metal-organic frameworks (MOFs), UiO-66 and UiO-66-NH, were considered as containers for bioactive chemicals. We provide a synthesis technique, which allowed the production of these materials suitable for biomedical applications. Both MOFs were characterized as single-phase porous materials composed of nanoparticles (30-65 nm) with a ζ-potential of more than 40 mV in water suspension.

Self-Driving Laboratories for Development of New Functional Materials and Optimizing Known Reactions.

Innovations often play an essential role in the acceleration of the new functional materials discovery. The success and applicability of the synthesis results with new chemical compounds and materials largely depend on the previous experience of the researcher himself and the modernity of the equipment used in the laboratory. Artificial intelligence (AI) technologies are the next step in developing the solution for practical problems in science, including the development of new materials.

ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles.

Synthesis of the MIL-100 metal-organic framework particles was carried out by hydrothermal (HT) and microwave (MW)-assisted methods. Transmission electron microscopy showed formation of microparticles in the course of hydrothermal synthesis and nanoparticles for microwave-assisted synthesis. Powder X-ray diffraction confirmed formation of larger crystallites for hydrothermal synthesis.

Vaporization and thermodynamics of ceramics in the Sm O -Y O -HfO system.

Rationale: The Sm O -Y O -HfO system holds promise for applications in the sphere of high-temperature technologies, particularly the development of ultra-high-temperature ceramics. However, the reliability of refractory materials is dependent on the possible selective vaporization of their components leading to changes in their physicochemical properties. Thus, information about vaporization processes and thermodynamic properties of ceramics based on the Sm O -Y O -HfO system may be of importance for the production of high-temperature materials as well as for the prediction of the physicochemical properties of ultra-high-temperature ceramics.

Global Variation in Use of Enteral Nutrition for Pediatric Crohn Disease.

Objectives: Exclusive enteral nutrition (EEN) is an effective induction treatment for pediatric Crohn disease. Given the center-based variation in use and diversity in practice, we constructed a survey aimed at sharing experience and strategies in administering EEN, stimulating further research, and optimizing therapy.

Methods: This survey was constructed after consultation with experts and designed to address key knowledge gaps.

Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes.

Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.