Oxidative stress-modifying effects of TiOnanoparticles with varying content of Ti(Ti) ions.

Nanoparticles (NPs) with reactive oxygen species (ROS)-regulating ability have recently attracted great attention as promising agents for nanomedicine. In the present study, we have analyzed the effects of TiOdefect structure related to the presence of stoichiometric (Ti) and non-stoichiometric (Tiand Ti) titanium ions in the crystal lattice and TiONPs aggregation ability on HO- and tert-butyl hydroperoxide (tBOOH)-induced ROS production in L929 cells. Synthesized TiO-A, TiO-B, and TiO-C NPs with varying Ti(Ti) content were characterized by x-ray powder diffraction, transmission electron microscopy, small-angle x-ray scattering, x-ray photoelectron spectroscopy, and optical spectroscopy methods.

Marine Polysaccharides Carrageenans Enhance Eryptosis and Alter Lipid Order of Cell Membranes in Erythrocytes.

Unlabelled: Aim In the current study, hemocompatibility of three major commercially available types of carrageenans (ι, κ and λ) was investigated focusing on eryptosis.

Materials And Methods: Carrageenans of ι-, κ- and λ-types were incubated with washed erythrocytes (hematocrit 0.4%) at 0-1-5-10 g/L for either 24 h or 48 h.

Rare-earth orthovanadate nanoparticles trigger Ca-dependent eryptosis.

. Rare-earth orthovanadate nanoparticles (ReVO:Eu, Re = Gd, Y or La) are promising agents for photodynamic therapy of cancer due to their modifiable redox properties. However, their toxicity limits their application.

Assessing the Cytotoxicity of TiO Nanoparticles with a Different Ti(Ti)/Ti Ratio.

Titanium dioxide (TiO) nanoparticles are promising biomedical agents characterized by good biocompatibility. In this study, we explored the cytotoxicity of TiO nanoparticles with a different Ti(Ti)/Ti ratio and analyzed the efficiency of eryptosis indices as a tool in nanotoxicology. Two types of TiO nanoparticles (NPs) were synthesized by the hydrolysis of titanium alkoxide varying the nitric acid content in the hydrolysis mixture.

Antimicrobial Effects of Nanostructured Rare-Earth-Based Orthovanadates.

The search for novel antimicrobial agents is of huge importance. Nanomaterials can come to the rescue in this case. The aim of this study was to assess the cytotoxicity and antimicrobial effects of rare-earth-based orthovanadate nanoparticles.

Experimental confirmation of antimicrobial effects of GdYVO:Eu nanoparticles.

Nanotechnology can be applied to design antibacterial agents to combat antibiotic resistance. The aim of the present study was to assess the antimicrobial effects and cytotoxicity of GdYVO:Eu nanoparticles (NPs). Biofilm inhibition activity, antimicrobial activity, bacterial viability inhibition and DNA cleavage activity of GdYVO:Eu NPs were studied.

UV Light-Activated GdYVO:Eu Nanoparticles Induce Reactive Oxygen Species Generation in Leukocytes Without Affecting Erythrocytes In Vitro.

Nanoparticles (NPs) have been reported to be promising enhancement agents for radiation therapy. The aim of the study was to assess the cytotoxicity of UV non-treated and UV pretreated GdYVO:Eu nanoparticles against erythrocytes and leukocytes by detecting eryptosis and reactive oxygen species (ROS) generation. Levels of intracellular ROS in erythrocytes and leukocytes using a ROS-sensitive dye 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA), as well as eryptosis rate utilizing annexin V staining, following direct exposure to UV-activated and nonactivated NPs were detected by flow cytometry.

Insight into the mechanism of the photoluminescence of carbon nanoparticles derived from cryogenic studies.

The unexpected discovery of the photoluminescence of carbon nanoparticles attracted the attention of many researchers and resulted in their use in a variety of applications. However, the origin of their emission is still obscure, and the majority of the discussions on the subject focus on their molecular and/or excitonic emissive states. We performed cryogenic studies down to 10 K and did not observe any signatures of suppressed molecular relaxation - the spectra remained broad, showing large unaltered Stokes shifts and temperature-independent emission intensities and lifetimes below 80 K with a weak dependence above this value.

Reactive oxygen species generation in aqueous solutions containing GdVO:Eu nanoparticles and their complexes with methylene blue.

It this letter, we report the study of free radicals and reactive oxygen species (ROS) generation in water solutions containing gadolinium orthovanadate GdVO:Eu nanoparticles (VNPs) and their complexes with methylene blue (MB) photosensitizer. The catalytic activity was studied under UV-Vis and X-ray irradiation by three methods (conjugated dienes test, OH· radical, and singlet oxygen detection). It has been shown that the VNPs-MB complexes reveal high efficiency of ROS generation under UV-Vis irradiation associated with both high efficiency of OH· radicals generation by VNPs and singlet oxygen generation by MB due to nonradiative excitation energy transfer from VNPs to MB molecules.

Oscillations of Cerium Oxidation State Driven by Oxygen Diffusion in Colloidal Nanoceria (CeO ).

The redox performance of CeO nanocrystals (nanoceria) is always accompanied by the switching of cerium oxidation state between Ce and Ce. We monitored Ce → Ce oxidation of nanoceria stimulated by oxidant in aqueous colloidal solutions controlling the luminescence of Ce ions located at different distances from nanoceria surface. The observed Ce luminescence changes indicate that Ce → Ce reaction develops inside nanoceria being triggered by the diffusing oxygen originated from the water splitting on oxidized nanoceria surface.