Publications by authors named "Pavel Kuznetsov"

Article Synopsis
  • The horse family (equids) has a rich fossil record showing significant evolutionary changes over the last 55 million years, with a wealth of ancient genomes sequenced to understand their domestication history.
  • This study generated genome-wide data from 25 ancient equid specimens spanning 44,000 years in regions like Anatolia and Mongolia, revealing the presence of extinct species and new insights into their survival.
  • The research also identified genetic differences among Asian wild asses and a common genetic signature in wild asses across continents, raising questions about the role of specific genetic changes in the extinction of certain equid species.
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Article Synopsis
  • - Horses transformed human mobility, but the timeline of their domestication and integration as transport is debated, with new genetic data being used to clarify this history.
  • - Analysis of 475 ancient horse genomes indicates that modern domestic horses were shaped by human intervention around 2200 BCE, after a domestication bottleneck began around 2700 BCE, leading to a significant expansion across Eurasia.
  • - Evidence also suggests that there was early horse husbandry in central Asia at Botai around 3500 BCE, prior to the establishment of contemporary horse bloodlines, challenging the notion of large herds being linked to migrations around 3000 BCE.
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The Yamnaya archaeological complex appeared around 3300BCE across the steppes north of the Black and Caspian Seas, and by 3000BCE reached its maximal extent from Hungary in the west to Kazakhstan in the east. To localize the ancestral and geographical origins of the Yamnaya among the diverse Eneolithic people that preceded them, we studied ancient DNA data from 428 individuals of which 299 are reported for the first time, demonstrating three previously unknown Eneolithic genetic clines. First, a "Caucasus-Lower Volga" (CLV) Cline suffused with Caucasus hunter-gatherer (CHG) ancestry extended between a Caucasus Neolithic southern end in Neolithic Armenia, and a steppe northern end in Berezhnovka in the Lower Volga.

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Phase evolution and strengthening of the FeNiCoCrMoAl powder alloy produced via inert gas atomization and annealed in the temperature interval of 300-800 °C have been studied by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, and microhardness testing. It was found that annealing at 300-600 °C leads to an increase of the element segregations between the several solid solutions with a rise of the lattice misfit to 1.5 % and microhardness growth to 1070 HV.

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In the present study, powder of FeCoCrNiMoAl HEA was manufactured by gas atomization process, and then used for laser powder bed fusion (L-PBF) and microplasma spraying (MPS) technologies. The processes of phase composition and microstructure transformation during above mentioned processes and subsequent heat treatment were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and differential thermal analysis (DTA) methods. It was found that gas atomization leads to a formation of dendrites of body centered cubic (BCC) supersaturated solid solution with insignificant Mo-rich segregations on the peripheries of the dendrites.

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Article Synopsis
  • The domestication of horses significantly changed mobility and warfare, but modern breeds do not trace back to the earliest domestic horses found in Central Asia around 3500 BC.
  • Research reestablishes the Western Eurasian steppes, particularly the lower Volga-Don area, as the origin of modern domestic horses, based on genetic analysis from 273 ancient horse genomes.
  • The study finds that the spread of modern domestic horses around 2000 BC coincided with the emergence of equestrian cultures, refuting the idea that horseback riding was linked to the expansion of Yamnaya pastoralists in Europe.
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During the Early Bronze Age, populations of the western Eurasian steppe expanded across an immense area of northern Eurasia. Combined archaeological and genetic evidence supports widespread Early Bronze Age population movements out of the Pontic-Caspian steppe that resulted in gene flow across vast distances, linking populations of Yamnaya pastoralists in Scandinavia with pastoral populations (known as the Afanasievo) far to the east in the Altai Mountains and Mongolia. Although some models hold that this expansion was the outcome of a newly mobile pastoral economy characterized by horse traction, bulk wagon transport and regular dietary dependence on meat and milk, hard evidence for these economic features has not been found.

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Bacterial nanocellulose (BNC) is a unique product of microbiological synthesis, having a lot of applications among which the most important is biomedicine. Objective complexities in scaling up the biosynthesis of BNC are associated with the nature of microbial producers for which BNC is not the target metabolite, therefore biosynthesis lasts long, with the BNC yield being small. Thus, the BNC scale-up problem has not yet been overcome.

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By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population.

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Article Synopsis
  • Horse domestication had a profound impact on warfare, travel, trade, and language spread.* -
  • The study analyzed DNA from 149 ancient horses, revealing two distinct extinct lineages from Iberia and Siberia that didn't significantly contribute to modern horses.* -
  • The Persian horse lineages gained traction after Islamic conquests, and modern breeding practices have dramatically affected genetic diversity in horses compared to earlier human management.*
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Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers.

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Article Synopsis
  • Researchers analyzed ancient DNA from 69 Europeans dating back 8,000 to 3,000 years using advanced techniques that reduced sequencing time significantly, enabling the study of more individuals.
  • They discovered that during the Neolithic period, diverse populations of early farmers emerged in Western Europe while Eastern Europe maintained a distinct hunter-gatherer population with ties to ancient Siberians.
  • The study also highlighted a major migration event around 4,500 years ago, where the Corded Ware people from Germany mixed heavily with steppe herders from the east, contributing to modern European ancestry and supporting the theory of a steppe origin for some Indo-European languages.
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