Publications by authors named "Pavel E Trakhtman"
Objective: Tissue susceptibility to histotripsy disintegration has been reported to depend on its elastic properties. This work was aimed at investigation of histotripsy efficiency for liquefaction of human hematomas, depending on their stiffness and degree of retraction over time (0-10 d).
Methods: As an in vitro hematoma model, anticoagulated human blood samples (200 mL) were recalcified at different temperatures.
Article Synopsis
- - The angiotensin-converting enzyme (ACE) plays a key role in regulating blood pressure and is linked to various health conditions, particularly cardiovascular diseases and granulomatous diseases, with elevated levels indicating potential health risks.
- - A new method called ACE phenotyping was used to investigate a specific donor's blood, revealing a unique conformational impairment in ACE, which is found in a small percentage of the healthy population and more frequently in patients with kidney issues.
- - The study linked increased ACE activity and a specific M71V genetic mutation to elevated levels of a natural ACE inhibitor and proposed that monitoring ACE conformational changes could also reflect free bilirubin levels in plasma, which has clinical implications for patient health assessments.
Large-volume soft tissue hematomas are a serious clinical problem, which, if untreated, can have severe consequences. Current treatments are associated with significant pain and discomfort. It has been reported that in an in vitro bovine hematoma model, pulsed high-intensity focused ultrasound (HIFU) ablation, termed histotripsy, can be used to rapidly and non-invasively liquefy the hematoma through localized bubble activity, enabling fine-needle aspiration.
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- - The case report discusses a successful recovery of ovarian function and spontaneous pregnancy in a patient with acute myeloblastic leukemia (AML) who underwent hematopoietic stem cell transplantation (HSCT) with a busulphan-based treatment.
- - After receiving hormone-replacement therapy (HRT) for hypergonadotropic hypogonadism one year post-HSCT, the patient experienced restored ovarian function within 12 months.
- - Although the patient initially confirmed a pregnancy with a detectable heartbeat at week 7, it ultimately resulted in a nondeveloping pregnancy, revealing a full triploid genotype (69 XXX) upon genetic examination.