Publications by authors named "Pavana Lakshmi Vaddavalli"
Article Synopsis
- - Formaldehyde (FA) is a harmful toxin linked to cancer and aging, with genetic mutations in detoxifying enzymes leading to its accumulation and severe health consequences in conditions like AMeD syndrome.
- - The study examined how various DNA repair systems in *C. elegans* respond to excessive FA, identifying three distinct repair mechanisms involved in managing FA-induced DNA damage throughout development and reproduction.
- - Results indicate that the Cockayne syndrome B (CSB) factor plays a key role in resolving FA-related DNA damage, and the antioxidant N-acetyl-l-cysteine (NAC) could offer a therapeutic approach to mitigate FA's harmful effects.
The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most frequently mutated gene in human cancers. p53 plays a central role in responding to DNA damage and determines the outcome of the DNA damage checkpoint response by regulating cell cycle arrest and apoptosis. As a consequence of this function, dysfunctional p53 results in cells that, despite a damaged genome, continue to proliferate thus fueling malignant transformation.
View Article and Find Full Text PDFRole of special cross-links in structure formation of bacterial DNA polymer.
J Phys Condens Matter
January 2018
Using data from contact maps of the DNA-polymer of Escherichia coli (E. Coli) (at kilobase pair resolution) as an input to our model, we introduce cross-links between monomers in a bead-spring model of a ring polymer at very specific points along the chain. Via suitable Monte Carlo simulations, we show that the presence of these cross-links leads to a particular organization of the chain at large (micron) length scales of the DNA.
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