Publications by authors named "Pavan Wakhare"
Lupus Nephritis Disguised: The Diagnostic Challenge of Eosinophilic Enteritis - A Case Report.
Middle East J Dig Dis
January 2024
Article Synopsis
- * A 33-year-old female presented with abdominal pain, infrequent loose stools, and joint pain, leading to various investigations including endoscopies, which revealed eosinophilic infiltration in the esophagus and colon, along with proteinuria indicating renal issues.
- * Ultimately, the patient was diagnosed with lupus nephritis Class 3 after renal biopsy, highlighting the importance of early detection and treatment to prevent severe complications and improve quality of life for SLE patients, especially when atypical symptoms occur. *
An 11-year-old patient presented with the primary complaint of hematuria and vomiting. On further investigation and a series of diagnostic tests, including a biopsy and thrombotic microangiopathy (TMA) profile, the patient was diagnosed with thrombotic microangiopathy. TMA is a pathological process involving endothelial cell injury, leading to thrombocytopenia and microangiopathic hemolytic anemia.
View Article and Find Full Text PDFBackground Glomerular filtration rate (GFR) estimation is pivotal in the evaluation of kidney donors. There are various methods available for assessing GFR, but there has been a lack of consensus on the measurement of GFR and the frequency of renal evaluation after kidney donation. Our study aims to analyze the measured GFR (m-GFR) before and three months after kidney donation and note the compensatory abilities of the remnant kidney in live related kidney donors.
View Article and Find Full Text PDFBackground Diabetic nephropathy is one of the important causes of end-stage kidney disease (ESKD). Of the various cytokines playing a role in the pathogenesis of diabetic nephropathy, transforming growth factor beta-1 (TGF-β1) is an important one. Its major role is to mediate extracellular matrix deposition.
View Article and Find Full Text PDFBackground The role of T-regulatory cells (Tregs) in inflammatory renal disease is not yet established. We attempted to study peripherally circulating T-cells expressing RORtFoxp3 dynamics in acute kidney injury (AKI) and chronic kidney disease (CKD). Aim To determine the role of T-regulatory cells in AKI and CKD.
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- The study evaluated kidney paired donations (KPDs) as a viable method to boost living donor kidney transplants in a program where traditional methods are limited by costs and complications.
- Conducted at a single center, the research involved 77 KPD transplants, noting various reasons for KPD use including ABO incompatibility and sensitization, and highlighted an overall 25% increase in living donor transplants over one year.
- The findings showed high success rates with excellent graft and patient survival, and shorter waiting times for KPD compared to deceased donor transplants, emphasizing the importance of a well-organized KPD registry and counseling efforts.
Article Synopsis
- - One-third of living kidney donors are rejected due to ABO blood type incompatibility and donor-specific antibodies, which leads to longer wait times and increased health risks for patients in need of a kidney transplant.
- - Kidney paired donation has become a prominent way to boost the number of living kidney transplants, particularly in regions with limited resources where incompatible transplants are not feasible.
- - Strategies to enhance kidney paired donation include compatible pairs, altruistic donor chains, and leveraging social media for awareness, along with the establishment of dedicated teams or a national program to improve access and efficiency in matching donors and recipients.
Article Synopsis
- In countries with limited resources for kidney transplants, kidney paired donation (KPD) can effectively increase living donor kidney transplants (LDKT), as shown by a study in India involving 300 KPD transplants from 2000 to 2016.
- The most common reasons for patients joining KPD included ABO incompatibility, positive cross-match, and better matching, leading to a variety of exchange configurations that successfully facilitated these transplants.
- The program demonstrated excellent patient outcomes, with high graft and patient survival rates, and highlights the importance of registry maintenance, patient counseling, and a strong teamwork approach to optimize transplant success.
Article Synopsis
- The study reports the first international living related two-way kidney paired donation (KPD) transplantation from India, which occurred on February 17, 2015, following legal approval.
- The procedure involved donor-recipients from Portugal and India who were highly sensitized and ABO incompatible, with successful negative cross-matching confirming compatibility for the exchange.
- The results demonstrated that both pairs had successful surgeries with good kidney function at 11 months post-transplant, highlighting international KPD as a promising solution to kidney shortages and improving outcomes for difficult-to-match patients.
Aim: To avoid desensitization protocols and ABO incompatible kidney transplantation (KT) due to high costs and increased risk of infections from intense immunosuppression.
Methods: We present institutional ethical review board - approved study of single center 6-way kidney exchange transplantation. The participants comprised ABO incompatibility ( = 1); positive cross-match and/or presence of donor specific antibody ( = 5).
The combination of kidney paired donation (KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation (LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient.
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