Publications by authors named "Pavan Kumar G S"
Article Synopsis
- Metastasis is a complicated disease that relies on specific protein interactions, such as Vimentin and NEDD9, which are crucial for cancer progression and treatment resistance.
- Withaferin A (WFA) is a natural compound thought to target Vimentin, potentially offering a way to inhibit metastasis, although its complete mechanism is still not clear.
- Research has utilized various techniques, including gene expression analysis and protein interaction assays, to demonstrate that targeting the Vimentin-NEDD9 interaction with WFA can reduce melanoma spread to the lungs, highlighting its potential as a therapeutic approach.
VEGFR1 (Flt-1), is a high-affinity tyrosine kinase receptor of VEGF found primarily on vascular endothelial cells. Recently, Flt-1 has shown to be expressed in human monocytes. However, the key intracellular signaling pathway mediated by Flt-1 receptor has been yet to be identified in monocytes.
View Article and Find Full Text PDFMitogenicity is the ability of the natural or synthetic compounds to induce cell division or proliferation. A series of salicylic acid derivatives containing isoxazoline moiety (8a-j) were synthesized and their immunopharmacological activities targeting lymphocyte proliferation and angiogenesis were evaluated. The compounds 8a-j mitogenicity were investigated on immunological cells that include human peripheral blood lymphocytes and murine splenocytes in-vitro.
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