A captivating approach to elevate the detection of Al ions incorporates the utilization of a tripodal receptor intricately embellishing the surface of zinc oxide.

The FDA (Food and Drug Administration, (USA)) lists ZnO as a material that is widely acknowledged to be safe. ZnO NPs with a range of tiny particle sizes were made using the precipitation process. ZnO nanoparticles' surface is embellished with a tripodal sensor containing naphthol units.

2-[()-(2-carboxybenzylidene) amino] ethan ammonium-like amino acid zwitterions: crystal structure, functional studies and its molecular dynamic simulation study with drug target receptors.

The novel synthetic amino acid-like zwitterion containing imine bond ionic compound 2-[()-(2-carboxy benzylidene) amino] ethan ammonium salt, CHNO was synthesized. Computational functional characterization is now being used to predict novel compounds. Here, we report on a titled combination that has been crystallizing in orthorhombic space group Pcc2 with  = 4.

Computational Studies on T2Rs Agonist-Based Anti-COVID-19 Drug Design.

The expeditious and world pandemic viral disease of new coronavirus (SARS-CoV-2) has formed a prompt urgency to discover auspicious target-based ligand for the treatment of COVID-19. Symptoms of novel coronavirus disease (COVID-19) typically include dry cough, fever, and shortness of breath. Recent studies on many COVID-19 patients in Italy and the United Kingdom found increasing anosmia and ageusia among the COVID-19-infected patients.

Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues.

Objectives: The aim of the present study is to carry out a simple synthesis of aminoantipyrine analogues and exploration of their antibacterial, cytotoxic, and anticonvulsant potential.

Methods: The compounds were characterized employing multi-spectroscopic methods. The in vitro pharmacological response of a series of bacteria was screened employing serial dilution method.

-based nanomedicine with enhanced biological applications: in vitro and in vivo approach.

This is the first study to report the green synthesis of mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and anti-fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested.

Unusual Fluorescence Quenching-Based Al Sensing by an Imidazolylpiperazine Derivative. β-Cyclodextrin Encapsulation-Assisted Augmented Sensing.

We report in this paper an unusual β-cyclodextrin mediated-aluminum (III) ion sensing based on augmented quenching of fluorescence. The fluorescent sensing of metal ions by a new ligand prepared (L = 4-[{4-(1H-imidazol-1-yl)phenyl]imino}methyl]piperazine-1-carboxaldehyde) has been investigated as well as the effect of the supramolecular complex formation with β-CD. In aqueous solution, L shows an increase of fluorescence due to the interaction with β-cyclodextrin with a formation constant of 77 (± 12) M.

Tuning the recognition properties of urea based receptor towards cyanide in aqueous medium: Effect of fluorine substitution on strength and selectivity of the anion receptor.

In this report, we have successfully tuned the selectivity and sensitivity of an anion receptor L by substituting electron withdrawing natured fluorine atoms directly on to the rim of the phenyl ring. Despite the fact that, we have two electron withdrawing natured nitro substituents on the other side of receptor L; two fluorine substitutions made dramatic change in the sensing ability as well as the selectivity of the receptor L towards anions. The acetonitrile solution contains L with tetrabutyl ammonium salts of fluoride, cyanide, acetate and dihydrogen phosphate results sudden color changes from yellow to brown; almost negligible spectral/color change for azide and bifluoride, where as there is no color change observed with any other anionic guests with L.

Differential Metal Ion Sensing by an Antipyrine Derivative in Aqueous and β-Cyclodextrin Media: Selectivity Tuning by β-Cyclodextrin.

β-Cyclodextrin (β-CD) is a nontoxic cyclic oligosachcharide that can encapsulate all or part of organic molecules of appropriate size and specific shape through noncovalent interaction. Herein, we report the influence of β-CD complex formation of an antipyrine derivative on its metal ion sensing behavior. In aqueous solution, the antipyrine shows a turn-on fluorescence sensing of vanadyl ion, and in cyclodextrin medium it senses aluminum ion.

Supramolecular complex binding to G-quadruplex DNA: Berberine encapsulated by a planar side arm-tethered β-cyclodextrin.

G-quadruplex-binders have the plausible potential to act as anticancer agents. Herein, the mode of binding of a synthesized fluorenyl derivative of β-cyclodextrin with a duplex and G-quadrulex DNAs has been investigated. Moreover, the loading of the well-known G-quadruplex binder, berberine, in the β-cyclodextrin derivative using 2-dimensional rotating-frame Overhauser effect spectroscopy is studied.

Electron-deficient tripodal amide based receptor: An exclusive turn-on fluorescent and colorimetric chemo sensor for cyanide ion.

Here in, we have designed, synthesized and isolated sensor L, as an exclusive selective turn-on fluorescent chemo sensor for cyanide ion. The acetonitrile solution contains L with tetrabutyl ammonium cyanide, results sudden color change from colorless to yellowish-brown. Chemosensor L produced a strong fluorescence response with an enhancement of very high fluorescence intensity while addition of CN ion and the strength of the chemosensor L towards cyanide binding is found to be 3.

A new fluorescent chemosensor for cadmium(II) based on a pyrene-appended piperidone derivative and its β-cyclodextrin complex.

We report, in this article, a piperidin-4-one derivative carrying pyrenyl fluorescent reporter groups which acts as a Cd ion sensor. The compound is synthesized and characterized using IR and NMR spectral techniques. The compound forms an inclusion complex with β-cyclodextrin.

A simply synthesized biphenyl substituted piperidin-4-one for the fluorescence chemosensing of Cd.

Ion-induced change in fluorescence is a straight-forward method for detection of toxic metal ions showing immediate response. Cadmium ions are toxic to the environment. We report in this paper a piperidine-4-one-based fluorescent chemosensor of Cd ions, designed and synthesized by a simple method.

Loading of atorvastatin and linezolid in β-cyclodextrin-conjugated cadmium selenide/silica nanoparticles: A spectroscopic study.

The preparation of β-cyclodextrin-conjugated cadmium selenide-silica nanoparticles, the loading of two drugs viz., Atorvastatin and linezolid in the cyclodextrin cavity, and the fluorescence energy transfer between CdSe/SiO2 nanoparticles and the drugs encapsulated in the cyclodextrin cavity are reported in this paper. IR spectroscopy, X-ray diffractometry, transmission electron microscopy, and particle size analysis by light-scattering experiment were used as the tools of characterizing the size and the crystal system of the nanoparticles.

On the accessibility of surface-bound drugs on magnetic nanoparticles. Encapsulation of drugs loaded on modified dextran-coated superparamagnetic iron oxide by β-cyclodextrin.

We report the loading of drugs on aminoethylaminodextran-coated iron oxide nanoparticles, their superparamagnetic behavior, loading of drugs on them, and the β-cyclodextrin-complex formation of the drugs on the surface of the nanoparticles. The magnetic behavior is studied using vibrating sample magnetometry and X-ray photoelectron spectroscopy is used to analyze the elemental composition of drug-loaded nanoparticles. Scanning electron microscopy shows ordered structures of drug-loaded nanoparticles.

Picking Out Logic Operations in a Naphthalene β-Diketone Derivative by Using Molecular Encapsulation, Controlled Protonation, and DNA Binding.

On-off switching and molecular logic in fluorescent molecules are associated with what chemical inputs can do to the structure and dynamics of these molecules. Herein, we report the structure of a naphthalene derivative, the fashion of its binding to β-cyclodextrin and DNA, and the operation of logic possible using protons, cyclodextrin, and DNA as chemical inputs. The compound crystallizes out in a keto-amine form, with intramolecular N-H⋅⋅⋅O bonding.

A Highly Selective Fluorescent Sensor for Pb(2+) Based on a Modified β-Cyclodextrin.

A modified cyclodextrin is synthesized as an anthracene derivative of 6-deoxy- 6-aminoethylamino-β-cyclodextrin and characterized using IR, NMR, and mass spectral techniques. The compound acts as a sensor of Pb(2+) ions in a pool of several metal ions, by enhancement of fluorescence. The absorption spectrum does not show significant changes on the addition of metal ions.