Malocclusion in children and adolescents with Down syndrome: A systematic review and meta-analysis.

Background: Previous studies have shown a high prevalence of malocclusion in people with Down syndrome (DS) compared to individuals without DS, but no systematic review to summarize the evidence on this topic has been performed thus far.

Aim: To evaluate whether children/adolescents with DS are more affected by malocclusion than those without DS.

Design: A search was performed in seven electronic databases.