Publications by authors named "Paulo Sergio Martins Alcantara"
Cancer cachexia affects about 80% of advanced cancer patients, it is linked to poor prognosis and to date, there is no efficient treatment or cure. The syndrome leads to progressive involuntary loss of muscle and fat mass induced by systemic inflammatory processes. The role of the white adipose tissue (WAT) in the onset and manifestation of cancer cachexia gained importance during the last decade.
View Article and Find Full Text PDFBackground: Contradictory results are reported for the role of angiopoietin-like 4 (ANGPTL-4) in the development of cancer-cachexia and inflammation, given its importance in angiogenesis and inflammatory signaling. Our aim was to analyze the levels of ANGPTL-4 in colorectal cancer patients with a stable weight and those with cachexia in order to establish a relationship between ANGPTL-4 and the inflammatory process.
Results: Plasma and tumor levels of ANGPTL-4 were higher in CC in comparison to other groups.
Background: Cancer cachexia (CC) is a multifactorial syndrome, often irreversible, that affects patients with cancer influenced, in part, by the inflammatory condition. Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, and growth factors; given the possible crosstalk between the peritumoural adipose tissue and tumour, these may play an important role in cancer biology and carcinogenesis.
Methods: The aim of this study was to evaluate the factors produced by peritumoural adipose tissue in a cohort of 16 colorectal cancer patients with either weight-stable cancer (WSC; n = 7) or CC (n = 9).
Background: Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectural remodeling in cachectic cancer patients.
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- Lymphangioma is a rare, benign tumor caused by a lymphatic system malformation, often found in the head, neck, and axilla but can occur anywhere in the body.
- In children, abdominal cystic lymphangiomas typically occur in the mesentery, causing symptoms like abdominal pain and intestinal obstruction.
- A case study is presented of a child with fever and abdominal pain, which led to surgery revealing a cystic lymphangioma that may be considered in diagnosing acute abdominal issues in pediatric patients.
NF-κBp65 and Expression of Its Pro-Inflammatory Target Genes Are Upregulated in the Subcutaneous Adipose Tissue of Cachectic Cancer Patients.
Nutrients
June 2015
Cancer cachexia, of which the most notable symptom is severe and rapid weight loss, is present in the majority of patients with advanced cancer. Inflammatory mediators play an important role in the development of cachexia, envisaged as a chronic inflammatory syndrome. The white adipose tissue (WAT) is one of the first compartments affected in cancer cachexia and suffers a high rate of lipolysis.
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- Angiomyolipomas (AMLs) are tumors made up of fat, muscle, and abnormal blood vessels, commonly found in the kidney and liver, and can vary in size and symptoms.
- There are two kinds of renal AMLs: isolated and those linked with tuberous sclerosis (TS), a genetic condition that can lead to other serious issues like pulmonary lymphangioleiomyomatosis (LAM).
- A case study highlighted a young woman's giant abdominal AML that caused severe pain and internal bleeding, leading to surgery, underscoring the importance of diagnosing AML and considering potential connections to TS for genetic counseling.
Article Synopsis
- Fibrosarcoma is a rare type of soft tissue cancer originating from fibrous connective tissue, primarily affecting individuals in their 40s and 50s, with various subtypes like low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma.
- A case study of a 53-year-old patient revealed a tumor initially misdiagnosed as a solitary fibrous tumor, but later identified as a hybrid of low-grade fibromyxoid and sclerosing epithelioid fibrosarcoma after recurrent lesions and metastases.
- The authors emphasize the challenges in diagnosing soft tissue tumors, stressing the need for extensive immunohistochemical testing to ensure accurate final diagnoses, particularly when clinical
The parotid is the most frequent site of primary salivary gland tumors. Lymphomas represent 0.2 to 0.
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