Critical analysis on the present methods for brain volume measurements in multiple sclerosis.

Objective: The treatment of multiple sclerosis (MS) has quickly evolved from a time when controlling clinical relapses would suffice, to the present day, when complete disease control is expected. Measurement of brain volume is still at an early stage to be indicative of therapeutic decisions in MS.

Methods: This paper provides a critical review of potential biases and artifacts in brain measurement in the follow-up of patients with MS.