Publications by authors named "Paulo Roberto Hrihorowitsch Moreno"
Acute myeloid leukemia (AML) belongs to a group of hematological cancer whose relapse cases are often associated with chemoresistance that impairs treatment success and contributes to a poor outcome. For this reason, there is an urgent need for the development of new therapeutic strategies. Herein, we explore the combination of venetoclax, a BCL2 inhibitor, and embelin, an XIAP inhibitor, in the AML cell lines.
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- Researchers tested nine Brazilian plant species for their ability to combat malaria by examining their extracts for antiplasmodial activity.
- The study focused on alkaloid and ethanol extracts against resistant and sensitive strains of Plasmodium falciparum, finding that alkaloid extracts were generally more effective.
- Notably, Guatteria australis showed the highest activity with an IC(50) of 0.3 microg/mL, with three species identified as promising for further research based on their low IC(50) values.