Effects of bioconversion by Battus polydamas on the chemical composition of Aristolochia spp. and evaluation of antimicrobial activity and biocompatibility.

Aristolochia plants are emblematic from an ethnopharmacological viewpoint and are know to possess numerous biological properties, including antiseptic. However, the medicinal potential of these species is debatable because of their representative chemical constituents, aristolochic acids (AAs) and aristolactams (ALs), which are associated, for instance, with nephropathy and cancer. These contrasting issues have stimulated the development of approaches intended to detoxification of aristoloquiaceous biomasses, among which is included the bioconversion method using larvae of the specialist phytophagous insect Battus polydamas, previously shown to be viable for chemical diversification and to reduce toxicity.

The Brazilian Longitudinal Study of Aging (ELSI-Brazil): Objectives and Design.

Brazil is experiencing among the world's fastest demographic aging worldwide. This demographic transition is occurring in a context of few resources and great social inequalities. The Brazilian Longitudinal Study of Aging (ELSI-Brazil) is a nationally representative study of 9,412 people aged 50 years or older, residing in 70 municipalities across the 5 Brazilian regions.

Capturing deaths not informed to the Ministry of Health: proactive search of deaths in Brazilian municipalities.

Introduction:: The proactive search of deaths is a strategy for capturing events that were not informed to the Mortality Information System of Ministry of Health. Its importance to reduce underreporting of deaths and to evaluate the operation of the information system is widely known.

Objective:: To describe the methodology and main findings of the Proactive Search of Deaths, 2013, establishing the contribution of different information sources.

[Use of vital data to estimate mortality indicators in Brazil: from the active search for events to the development of methods].

The article addresses Brazil's historical development in the use of vital data, incorporating procedures for the evaluation of such data and research with active search of births and deaths, resulting in the proposal of methods for calculating birth and mortality indicators through the use of continuous records. In addition to research to capture vital events from the years 2000 and 2008, the article presents procedures for the correction of events reported to the information systems and the paradigm shift in the method for calculating mortality indicators, resulting from such initiatives. The study also features advances in the adequacy of information on deaths and live births in Brazil, changes in the estimates on infant mortality resulting from the proposed methods, and the challenge of estimating the indicator for subnational geographic areas with lower population contingents, mostly consisting of municipalities (counties) with low and irregular data coverage.

Determinants of infant mortality in the Jequitinhonha Valley and in the North and Northeast regions of Brazil.

Objective: This study aims to identify the social and demographic determinants, in addition to the determinants of reproductive health and use of health services, associated with infant mortality in small and medium-sized cities of the North, Northeast and Southeast regions of Brazil.

Methods: This is a case-control study with 803 cases of death of children under one year and 1,969 live births (controls), whose mothers lived in the selected cities in 2008. The lists of the names of cases and controls were extracted from the Sistema de Informação sobre Mortalidade (SIM - Mortality Information System) and the Sistema de Informação sobre Nascidos Vivos (SINASC - Live Birth Information System) and supplemented by data obtained by the research of "active search of death and birth".

Alcohol abuse and involvement in traffic accidents in the Brazilian population, 2013.

Abstract This article aims to analyze alcohol abuse and frequent consumption according to sociodemographic characteristics and investigate the risk of greater involvement in traffic accidents, using data from the National Health Survey (PNS), 2013, Brazil. Events investigated were alcohol abuse and frequent consumption and if the individual was involved in a traffic accident and sustained an injury in the last 12 months. We investigated both events according to sociodemographic characteristics and assessed the association among them through multivariate logistic regression.

Estimation of HIV incidence in two Brazilian municipalities, 2013.

Objective: To estimate HIV incidence in two Brazilian municipalities, Recife and Curitiba, in the year of 2013.

Methods: The method for estimating incidence was based on primary information, resulting from the Lag-Avidity laboratory test for detection of recent HIV infections, applied in a sample of the cases diagnosed in the two cities in 2013. For the estimation of the HIV incidence for the total population of the cities, the recent infections detected in the research were annualized and weighted by the inverse of the probability of HIV testing in 2013 among the infected and not diagnosed cases.

Butterflies of the Bodoquena Plateau in Brazil (Lepidoptera, Papilionoidea).

Butterflies and moths are found in all terrestrial environments and require efforts for a better understanding of its mega-diversity. These taxa have been the subject of several studies involving phylogeny, ecology and environmental impacts. Nevertheless, several areas in the tropics remain unexplored, resulting in gaps in the taxonomic composition and distribution of butterflies in endemic environments.

Prenatal testing and prevalence of HIV infection during pregnancy: data from the "Birth in Brazil" study, a national hospital-based study.

Background: The rate of vertical HIV transmission has decreased in Brazil, but regional inequalities suggest problems in implementing control measures during pregnancy and delivery. The aims of this study were to ascertain the coverage of HIV testing during prenatal care and estimate the prevalence of HIV infection during pregnancy in Brazil.

Methods: This was a national hospital-based study of 23,894 women that was conducted in 2011-2012.

Disordered eating behaviors in adolescents and adults living in the same household in metropolitan area of Rio de Janeiro, Brazil.

Objective: To examine the prevalence of disordered eating behaviors among adolescents and adults living in the same household.

Methods: We conducted a population-based cross-sectional study developed with a probabilistic sample of 511 adolescents and 1254 adults living in the metropolitan area of Rio de Janeiro, Brazil. The frequency of binge eating, purging, and strict dieting or fasting over the previous 6 months was ascertained using a self-report questionnaire.

[Adequacy of weight gain in pregnant women from two municipalities of Rio de Janeiro state (RJ), Brazil, 2008].

Purpose: To evaluate sociodemographic, behavioral and reproductive factors and morbidities associated with inadequate weight gain during pregnancy.

Methods: Cohort study conducted from December 2007 to August 2008 with women in the first trimester of pregnancy looking for prenatal care in the Public Health System who lived in the cities of Petrópolis or Queimados, Rio de Janeiro state (Brazil). Women with multiple pregnancy, who had a miscarriage in the index pregnancy or who lacked information for the assessment of pregravid nutritional status or weight gain were excluded.

Prevalence of intestinal parasites versus knowledge, attitudes, and practices of inhabitants of low-income communities of Campos dos Goytacazes, Rio de Janeiro State, Brazil.

Intestinal parasites are the causative agents of common infections responsible for significant public health problems in developing countries and generally linked to lack of sanitation, safe water, and improper hygiene. More than two billion people throughout the world live with unrelenting illness due to intestinal parasitic infections (IPIs). The purposes of this study are to assess knowledge, attitudes, and practices on IPIs and investigate the relationship with prevalence of intestinal parasites among a low-income group of inhabitants from two communities of the Travessão District area, Campos dos Goytacazes, north of Rio de Janeiro State, Brazil.

Delay in introducing antiretroviral therapy in patients infected by HIV in Brazil, 2003-2006.

Purpose: To characterize the population of HIV+ Brazilian patients with late introduction of antiretroviral therapy (ARVT), using information from the Laboratory Exam Control System.

Methods: The study analyzed 84,694 patients, representing all individuals in Brazil age 15 or over with an initial CD4+ T lymphocyte count requested between 2003 and 2006, and whose ARVT start date was later than their initial CD4+ T cell count. These patients were considered antiretroviral treatment naive.

[Infant mortality estimation in Brazil: what do Ministry of Health data on deaths and live births say?].

A methodological approach to infant mortality estimation in Brazil based on vital information provided by Ministry of Health systems is presented. The study evaluated the available data to establish criteria for identifying municipalities with serious data deficiencies, proposing an adequacy index. All municipalities were classified in strata according to geographic region and adequacy of information.