The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons.

Background: Both genetic and environmental factors affect the risk of colorectal cancer (CRC).

Objective: We aimed to examine the interaction between the D1822V polymorphism of the APC gene and dietary intake in persons with CRC.

Design: Persons with CRC (n = 196) and 200 healthy volunteers, matched for age and sex in a case-control study, were evaluated with respect to nutritional status and lifestyle factors and for the D1822V polymorphism.