Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder.

Objective: Circadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.

Methods: This is a genetic association case (BD) vs.

Managing severe behavioral symptoms of a patient with anti-NMDAR encephalitis: case report and findings in current literature.

Objective: Psychiatric symptoms emerge in the early stages of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, and patients often seek treatment in psychiatric departments before visiting any other general medical services. Numerous articles about anti-NMDAR encephalitis have been published in the scientific community worldwide, but few emphasize the role of psychiatry in symptom management.

Case Description: We describe the case of a patient with anti- -NMDAR encephalitis seen in our service and discuss the management of behavioral symptoms based on current scientific literature.

Significant sleep disturbances in euthymic bipolar patients.

Objective: A growing amount of data suggests that sleep dysfunction is frequently observed in bipolar disorder (BD) patients even when they do not fulfill the criteria for major mood episodes. Thus, we performed a case-control study assessing sleep status in a group of euthymic BD patients and a group of health controls.

Methods: A total of 209 subjects (104 health controls and 105 BD patients) were enrolled in the study.