Publications by authors named "Paulo Henrique Moreira Melo"
Article Synopsis
- Appendicitis is the most common surgical emergency in children, and a study analyzed how well the Brazilian public healthcare system handles it based on various hospital features and patient profiles.
- In 2022, nearly 30,000 pediatric appendectomies were performed, with over 90% being open surgeries, predominantly in basic-facility general hospitals.
- Although full-facility hospitals had higher costs for surgeries, the overall mortality rate was low across all hospital types, indicating that children received adequate care regardless of the facility's resources.
Article Synopsis
- The study investigates trends in Pediatric Sickle Cell Disease (SCD) in Brazil from 2008 to 2022, focusing on incidence, mortality rates, and healthcare costs associated with the disease.
- It analyzed data from 81,942 hospitalizations, finding that 74.08% were crisis-related, with higher rates in males and children under five, particularly in the Southwest region of Brazil.
- The results indicate a need for targeted interventions to improve early detection and healthcare access, suggesting that addressing these factors can help manage the significant burden of SCD in pediatric populations.
Background: The atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy associated with high morbidity and high mortality. Eculizumab, a humanized anti-C5 monoclonal antibody, was the first medication approved for treating aHUS in 2011.
Objective: The objective of this study is to evaluate the efficacy and safety of eculizumab treatment in pediatric patients with aHUS.