Publications by authors named "Paulo Henrique Jacob Silva"
Article Synopsis
- Viruses typically invade cells by attaching to specific molecules on the cell surface, prompting the development of broad-spectrum multivalent entry inhibitors (MEIs) that can mimic these binding sites.
- To enhance the effectiveness of MEIs, modifications with hydrophobic arms create irreversible inhibition, which maintains efficacy even when diluted, though initial MEIs showed limited reversible inhibition against SARS-CoV-2.
- Through systematic testing, researchers identified effective small molecules that achieve irreversible inhibition against various viruses, demonstrating success in preventing SARS-CoV-2 infection in a hamster model using both intranasal and aerosol methods.
Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusogenic proteins, assisted by membrane cholesterol and calcium ions, provide the mechanical energy necessary to achieve vesicle fusion in neuromediator release.
View Article and Find Full Text PDFHere we present a method to extract thermodynamic quantities for nanoparticle dispersions in solvents. The method is based on the study of tomograms obtained from cryogenic electron tomography (cryoET). The approach is demonstrated for gold nanoparticles (diameter < 5 nm).
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