Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis.

Background: Tuberculosis (TB) is one of the top ten causes of death worldwide, while Chagas disease (CD) is the parasitic disease that kills the largest number of people in the Americas. TB is the leading cause of death for patients with AIDS; it kills 1.5 million people and causes 10 million new cases every year.

Methodological evaluation of 2-DE to study root proteomics during nematode infection in cotton and coffee plants.

The identification of plant proteins expressed in response to phytopathogens is a remaining challenge to proteome methodology. Proteomic methods, such as electrophoresis and mass spectrometry have been extensively used for protein differential expression studies in several plants including Arabidopsis thaliana, rice, and wheat. However, in coffee (Coffea canephora) and cotton (Gossypium hirsutum), bidimensional electrophoresis (2-DE) analysis has been rarely employed.

Rooteomics: the challenge of discovering plant defense-related proteins in roots.

In recent years, a strong emphasis has been given in deciphering the function of genes unraveled by the completion of several genome sequencing projects. In plants, functional genomics has been massively used in order to search for gene products of agronomic relevance. As far as root-pathogen interactions are concerned, several genes are recognized to provide tolerance/resistance against potential invaders.