Unilateral Ptosis in a 72-Year-Old Male: Early Diagnosis of Myasthenia Gravis Using the Ice Pack Test.

Ptosis, or eyelid drooping, can be an early indicator of various neurological and muscular disorders, underscoring the need for accurate diagnosis to ensure proper management. Myasthenia gravis (MG), a neuromuscular disorder, may initially present with isolated ocular symptoms, often resulting in diagnostic delays. This report details the case of a 72-year-old male who presented to the emergency department with a two-week history of progressive unilateral ptosis.

Marchiafava-Bignami Disease: A Case Report of a Reversible Cause of Dementia.

Marchiafava-Bignami disease (MBD) is a rare neurological disorder predominantly associated with chronic alcohol use, characterized by demyelination and necrosis of the corpus callosum. The condition often presents with cognitive dysfunction, motor deficits, and altered consciousness, which can range from mild confusion to severe stupor. Early recognition and treatment are crucial for improving outcomes.

Nature-based solutions in spatial planning and policies for climate change adaptation: A literature review.

Nature-based solutions (NbSs) are recognised as relevant to spatial planning in addressing societal challenges, although their uptake is limited and fragmented to some case studies, and difficulties emerge from their implementation and operationalisation. The research developed a literature review to investigate how NbS has been considered for its implementation and operationalisation in spatial planning and how NbS has been included across different policy instruments and used to address climate change adaptation (CCA). The results highlighted: Firstly, the review contributed to bridge the gap in NbS implementation and operationalisation by proposing a novel three-dimensional categorisation system to guide the selection of suitable NbS principles to address societal challenges; secondly, this study still revealed gaps in some policy areas, despite the effort to extensively apply NbS across diverse policy instruments to CCA.

The interplay between climate change and ageing: A systematic review of health indicators.

Climate change and rapid population ageing pose challenges for communities and public policies. This systematic review aims to gather data from studies that present health indicators establishing the connection between climate change and the physical and mental health of the older population (≥ 65 years), who experience a heightened vulnerability to the impacts of climate change when compared to other age cohorts. This review was conducted according to the PICO strategy and following Cochrane and PRISMA guidelines.

Salvage cryotherapy for prostate cancer.

Background: Most men diagnosed with prostate cancer will be candidates for active treatment and 20 to 50% of patients treated with organ preserving strategies recur within the prostate. Optimal treatment of recurrence is controversial. Prostate cryosurgery has been increasingly used as primary, recurrence and focal treatment for prostate cancer.

Adaptive DCS-SOMP for Localization Parameter Estimation in 5G Networks.

In this work, we model a 5G downlink channel using millimeter-wave (mmWave) and massive Multiple-Input Multiple-Output (mMIMO) technologies, considering the following localization parameters: Time of Arrival (TOA), Two-Dimensional Angle of Departure (2D-AoD), and Two-Dimensional Angle of Arrival (2D-AoA), both encompassing azimuth and elevation. Our research focuses on the precise estimation of these parameters within a three-dimensional (3D) environment, which is crucial in Industry 4.0 applications such as smart warehousing.

First Report of Myrtle Rust Caused by in (Camb.) Berg in Brazil.

is a Brazilian fruit tree that has ecological importance and the potential to be explored by the food and medical industries (Lima et al., 2011). In February 2019, in the experimental orchard at the Universidade Tecnológica Federal do Paraná, Dois Vizinhos city, Paraná State - Brazil, disease symptoms were observed on leaves, stems, and fruits of 22 trees.

[Human Rabies: Optimization of Prevention and Paths Towards the Cure].

Introduction: Rabies is one of the oldest and deadliest infectious diseases known by human beings and is commonly transmitted by animal bites. Dogs have a major role in the transmission of the virus. Rabies has no approved curative therapy, and its prevention, even though it is highly effective, it is complex, expensive and challenging in terms of accessibility, particularly regarding immunoglobulin.

Influence of sociodemographic factors on treatment's choice for localized prostate cancer in Portugal.

Introduction: Patients with localized prostate cancer (PCa) are active participants in the choice of treatment.

Objectives: To access the effects of social and demographic factors in the choice of treatment in cases of localized PCa, in a Portuguese population.

Methods: Identification of all patients with the diagnosis of localized PCa in the last four years in an oncological centre.

Prognostic value of p16INK4a overexpression in penile cancer.

Introduction: Penile cancer is rare, accounting for less than 1% of all male cancers in industrialized countries. It is most common in areas of high prevalence of HPV, being a third of cases attributed to the carcinogenic effect of HPV. Tumour cells infected with HPV overexpress p16INK4a, as such p16INK4a has been used as a surrogate of HPV infections.

Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles.

Diesel exhaust particles (DEP) are known to generate reactive oxygen species in the respiratory system, triggering cells to activate antioxidant defence mechanisms, such as Keap1-Nrf2 signalling and autophagy. The aim of this study was to investigate the relationship between the Keap1-Nrf2 signalling and autophagy pathways after DEP exposure. BEAS-2B cells were transfected with silencing RNA (siRNA) specific to Nrf2 and exposed to DEP.

Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence Surveillance of Patients With Non-Muscle-Invasive Bladder Cancer in a Comprehensive Multicenter Study.

Bladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70-75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR).

Evaluation of mobility, bioavailability and toxicity of Pb and Cd in contaminated soil using TCLP, BCR and earthworms.

The objective of the present study was to investigate the reduction of mobility, availability and toxicity found in soil contaminated with lead (Pb) and cadmium (Cd) from Santo Amaro Municipality, Bahia, Brazil using two combined methods, commonly tested separately according to the literature: metal mobilization with phosphates and phytoextraction. The strategy applied was the treatment with two sources of phosphates (separately and mixed) followed by phytoremediation with vetiver grass (Vetiveria zizanioides (L.)).

Metabolic syndrome and sexual (dys)function.

Introduction: The general worldwide increase in metabolic syndrome (MS) among most populations may result in more individuals with sexual dysfunction.

Aim: To provide an update on clinical and experimental evidence regarding sexual dysfunction in patients with MS from both sexes and treatment modalities.

Methods: A comprehensive literature review was performed using MEDLINE with the MeSH terms and keywords for "metabolic syndrome,""obesity,""female sexual dysfunction,""erectile dysfunction,""androgen deficiency,""weight loss," and "bariatric surgery.

[Ocular changes during pregnancy].

Pregnancy can cause several alterations in human eye function in healthy condition as well in ocular disease; these effects on the eyes are divided into three categories: physiologic alterations, ocular diseases changes already existing before the pregnancy, and pathological alterations. The present text proposes a bibliographical revision on the theme. The authors researched PubMed (MEDLINE) and LILACS databases.

Potential of carbon accumulation in no-till soils with intensive use and cover crops in southern Brazil.

The area under no-till (NT) in Brazil reached 22 million ha in 2004-2005, of which approximately 45% was located in the southern states. From the 1970s to the mid-1980s, this region was a source of carbon dioxide to the atmosphere due to decrease of soil carbon (C) stocks and high consumption of fuel by intensive tillage. Since then, NT has partially restored the soil C lost and reduced the consumption of fossil fuels.

[Occupational accidents treated in an emergency room].

In Brazil, work-related injuries are only reported to the National Social Security data system. Therefore, records are limited to formally hired workers, who represent less than half of the active work force. In this cross-sectional study, cases of work-related injuries were identified and interviewed in an emergency room in the city of Salvador, capital of Bahia State, Brazil, to estimate their frequency and characteristics.