Publications by authors named "Paulo Cesar Canary"
Article Synopsis
- - The study aimed to explore how bone marrow (BM) cells contribute to liver fibrosis using a chimeric mouse model, where bone marrow was replaced after irradiation, and liver injury was induced with carbon tetrachloride (CCl(4)).
- - Results indicated that liver injury resulted in structural changes and increased collagen deposition, but bone marrow cells did not differentiate into myofibroblasts, as shown by the lack of co-localization with fluorescently labeled cells.
- - Flow cytometric analysis revealed an increased presence of inflammatory bone marrow-derived cells in the liver, implying their role in inflammation rather than direct contribution to fibrosis.
Purpose: To investigate changes in cardiac functional parameters and the cardiac expression of angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1), procollagen type I (proc-I) and transforming growth factor-ß1 (TGF-ß1) in rats irradiated at heart.
Material And Methods: Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-ß1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting.
The objective of this paper was to evaluate the efficacy of a hypofractionated radiation protocol for feline facial squamous cell carcinoma (SCC). Twenty-five histologically confirmed SCCs in 15 cats were treated with four fractions of 7.6-10Gy each, with 1 week intervals.
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