Relevance of target-organ lesions as predictors of mortality in patients with diabetes mellitus.

Background: Patients with diabetes are in extract higher risk for fatal cardiovascular events.

Objective: To evaluate major predictors of mortality in subjects with type 2 diabetes.

Methods: A cohort of 323 individuals with type 2 diabetes from several regions of Brazil was followed for a long period.

A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using solid phase extraction for the simultaneous determination of plasma concentrations of enalapril and enalaprilate in hypertensive patients treated with different pharmaceutical formulations.

Unlabelled: Enalapril maleate, available on the market in a variety of different pharmaceutical formulations, is commonly used for the control of systemic arterial hypertension. Many therapeutical failures have been reported thus far in clinical practice with respect to switching between different pharmaceutical formulations of the same product during pharmacological therapy. In the present study, plasma concentrations of enalapril and enalaprilate were measured in hypertensive patients undergoing treatment with different pharmaceutical formulations.