Comparison of methotrexate, actinomycin D, and etoposide for treating low-risk gestational trophoblastic neoplasia.

Objective: To compare the efficacy and toxicity of 3 single agent chemotherapeutic regimens in low-risk gestational trophoblastic neoplasia (LRGTN).

Methods: A prospective study was conducted at a referral center in Rio de Janeiro, Brazil. Patients presenting with metastatic or non-metastatic LRGTN (risk score ≤ 6) in non-probabilistic sampling were assigned to 1 of 3 treatments: methotrexate with folinic acid rescue (MTX-CF; n=20); actinomycin D (n=20); and etoposide (n=20).

Gestational trophoblastic disease: Regional perspective in Rio de Janeiro, Brazil.

Objective: To give an overview of gestational trophoblastic disease in a referral center in Rio de Janeiro, Brazil.

Study Design: From January 1960 to December 2008, 4,290 registered patients were followed at the Gestational Trophoblastic Neoplasia Referral Center of Rio de Janeiro. All cases of complete and partial moles and of gestational trophoblastic neoplasia (GTN) were included and analyzed.

Maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian women.

Objective: To evaluate maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia (GTN) in Brazilian patients.

Methods: This study included 252 subsequent pregnancies after chemotherapy for GTN treated between 1960-2005. Correlations of maternal and perinatal outcomes with chemotherapy regimen (single or multiagent) and the time interval between chemotherapy completion and first subsequent pregnancy were investigated.