Publications by authors named "Paulo Assis Melo"
Article Synopsis
- This study explored the harmful effects of Lomonia obliqua venom, which causes serious health issues like blood clotting disorders and hemolysis in humans.
- In laboratory tests, the venom was found to be capable of clotting human plasma and destroying red blood cells, but its coagulation effects could be blocked by certain marine algal extracts.
- The algal extracts from Canistrocarpus cervicornis, Stypopodium zonale, and Dictyota pfaffi showed potential in inhibiting blood clotting caused by the venom, suggesting that marine algae could serve as a basis for developing antivenom treatments.
Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-function relationship studies and highlighting the mechanism of action and role of the snake venom PLA(2)s products, the lysophosphatidylcholine.
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