Toxic and trace metal concentrations in liver and kidney of dogs: influence of diet, sex, age, and pathological lesions.

The aim of this study was to provide data on the main toxic and trace metals in the liver and kidney of domestic dogs in Galicia, NW Spain and to evaluate the influence of diet, sex, age, and pathological lesions on metal accumulation. Samples of the liver and kidney from 77 male and female dogs, aged between 6 mo and 18 yr, were collected during ordinary necropsy. Samples were acid-digested and metal concentrations determined by inductively coupled plasma (ICP)-mass spectrometry and ICP-atomic emission spectrometry.

Effects of long-term dietary supplementation of monensin or saccharomyces cerevisiae on blood acid-base and productive performance in growing feedlot steers.

The aim of this study was to evaluate the effects of two dietary supplements (monensin and a live yeast culture) on acid-base balance in steers maintained in a commercial feedlot system, considering effects over the growing period (14 to 23 weeks of age). A 63-day feedlot study was performed using 42 double-muscled Belgian Blue steers. Steers were allotted randomly to one of the three study groups: (1) control group [no supplementation, C], (2) monensin supplementation [MON] at a concentration of 30 mg/kg (DM basis), and (3) live Saccharomyces cerevisiae strain supplementation [SACC] at a dose of 500 mg/kg (DM basis).

Effects of nifedipine, verapamil and diltiazem on serum biochemical parameters and aortic composition of atherosclerotic chickens.

Calcium appears to be involved in many of the cellular events, which are thought to be important in atherogenesis. In this study, we examine the effects of three calcium entry blockers (nifedipine, verapamil, and diltiazem at clinical and higher doses) on serum biochemical parameters and aortic calcium, cholesterol and triglyceride concentrations of atherosclerotic egg-fed chickens. All egg-fed chickens (treated and non-treated) showed an increase in serum total cholesterol, LDL-cholesterol and triglycerides without significant effect when calcium entry blockers were used.

Renal handling of calcium and phosphorus in experimental renal hyperparathyroidism in dogs.

Twenty-four hour urinary excretion, fractional excretion and the filtered load of calcium and phosphorus were monitored as hyperparathyroidism evolved in a model of progressive canine renal failure. Thirteen beagles of both sexes aged four and a half months were used. Nine of them were subjected to a renal damaging schedule (neomycine, 60 mg/kg/48 h, IM, 32 weeks) in order to induce chronic renal failure leading to secondary hyperparathyroidism (2HPT group).