Publications by authors named "Pauline Roux-Claude"
Background: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics.
Purpose: We aim to describe asthma control and healthcare consumption of severe asthma patients treated with biologics.
Background: Around 20% of people with cystic fibrosis (pwCF) do not have access to the triple combination elexacaftor/tezacaftor/ivacaftor (ETI) in Europe because they do not carry the F508del allele on the CF transmembrane conductance regulator () gene. Considering that pwCF carrying rare variants may benefit from ETI, including variants already validated by the US Food and Drug Administration (FDA), a compassionate use programme was launched in France. PwCF were invited to undergo a nasal brushing to investigate whether the pharmacological rescue of CFTR activity by ETI in human nasal epithelial cell (HNEC) cultures was predictive of the clinical response.
View Article and Find Full Text PDFBackground: Cardiopulmonary exercise testing (CPET) is an important clinical tool that provides a global assessment of the respiratory, circulatory and metabolic responses to exercise which are not adequately reflected through the measurement of individual organ system function at rest. In the context of critical COVID-19, CPET is an ideal approach for assessing long term sequelae.
Methods: In this prospective single-center study, we performed CPET 12 months after symptom onset in 60 patients that had required intensive care unit treatment for a severe COVID-19 infection.
Article Synopsis
- The study investigated the prevalence and characteristics of sleep apnea (SA) in patients who were hospitalized in the ICU for severe COVID-19, focusing on their apnea hypopnea index (AHI) three months post-illness.
- Out of 68 patients, a staggering 91% developed SA, with 44 individuals experiencing moderate to severe cases, while 62% of patients had other health issues, like obesity and hypertension.
- The findings emphasize the need for sleep assessments after ICU care for COVID-19, as those with moderate to severe SA had more severe COVID-19 symptoms and longer hospital stays.
Introduction: Survivors of viral ARDS are at risk of long-term physical, functional and neuropsychological complications resulting from the lung injury itself, but also from potential multiorgan dysfunction, and the long stay in the intensive care unit (ICU). Recovery profiles after severe SARS-CoV-2 pneumonia in intensive care unit survivors have yet to be clearly defined.
Material And Methods: The goal of this single-center, prospective, observational study was to systematically evaluate pulmonary and extrapulmonary function at 12 months after a stay in the ICU, in a prospectively identified cohort of patients who survived SARS-CoV-2 pneumonia.