Publications by authors named "Pauline Roumeguere"
Article Synopsis
- The study aimed to compare the effectiveness of surgical closure versus just seton removal for treating fistulizing perianal Crohn's disease in patients being treated with adalimumab.
- A randomized controlled trial involved 64 patients, where one group received surgical closure and seton removal, while the other group only had the seton removed.
- Results showed no significant difference in fistula closure rates between the two groups at 12 months, suggesting that seton removal alone may be just as effective as additional surgical intervention.
Background: Infliximab is the only medical therapy that has been proven to be effective in fistulizing Crohn's disease (CD), but the recurrence rate of fistulas is high despite maintenance therapy. The aim of this prospective study was to evaluate the short- and long-term efficacy of a combined schedule with infliximab, methotrexate, and sphincter-sparing surgery in patients with severe fistulizing anoperineal CD.
Methods: From January 2006 to November 2007, all consecutive patients in three referral centers with severe fistulizing anoperineal CD were prospectively included after primary drainage.