Publications by authors named "Pauline Martins"
Background: Polyclonal hypergammaglobulinaemia (PH) represents a classic diagnosis problem in internal medicine. However, there is no consensus threshold for PH. The aim of this study was to define a threshold for PH.
View Article and Find Full Text PDFObjective: To help identify homogeneous subgroups among patients with anti-PM-scleroderma-antibodies (PM-Scl-Abs) positive auto-immune diseases regardless of diagnostic classifications.
Material And Methods: This multicentric (four hospitals) retrospective study collected all consecutive patients (from 2011 to 2021) with positive testing for anti-PM-Scl-Abs in a context of CTD. Subgroups of patients with similar clinico-biological phenotypes were defined using unsupervised multiple correspondence analysis and hierarchical clustering analysis of the features recorded in the first year of follow-up.
Article Synopsis
- Polyclonal hypergammaglobulinaemia (PH) is a common diagnostic challenge in internal medicine, and this study aimed to establish a consensus threshold for PH based on serum protein electrophoresis (SPE) data from 2016.
- The researchers analyzed data from over 20,700 SPEs across three hospitals and found that the 95th percentile threshold for PH was 18.9 g/L, noting variations based on geographical regions.
- The study concludes that while the 19 g/L threshold may be significant, its biological nature requires validation through future prospective studies to determine its clinical relevance.
Background: Isavuconazole is a new antifungal prodrug for the treatment of invasive aspergillosis and mucormycosis. As no clear pharmacokinetic-pharmacodynamic relationship has been established for patients, therapeutic drug monitoring is not currently required. However, as isavuconazole is a new drug, clinicians are sometimes sceptical about the exposure achieved in their patients and seek pharmacokinetic exploration.
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