Publications by authors named "Pauline Lelandais"
Human fetal gonads acquire endocrine steroidogenic capabilities early during their differentiation. Genetic studies show that this endocrine function plays a central role in the sexually dimorphic development of the external genitalia during fetal development. When this endocrine function is dysregulated, congenital malformations and pathologies are the result.
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- - Modern living is negatively impacting female reproductive health, leading to a rise in reproductive disorders and declining birth rates, likely due to increased exposure to various chemicals.
- - Establishing clear cause-effect links between chemical exposure and reproductive issues has been challenging, complicating risk assessments for women's health.
- - This review proposes ten potential adverse outcome pathways (AOPs) focused on how chemical exposure affects female reproduction, particularly the ovaries, aiming to enhance safety assessments and protect women's reproductive health.