Publications by authors named "Pauline Lambert"
Introduction: The seasonal flu is a very important reason for consultation every winter. Symptoms can quickly progress to severe pneumonia. Currently, few tools exist to assess the clinical severity of patients.
View Article and Find Full Text PDFObjectives: Maraviroc may reduce hepatic inflammation in people with HIV and non-alcoholic fatty liver disease (HIV-NAFLD) through CCR5-receptor antagonism, which warrants further exploration.
Methods: We performed an open-label 96-week randomised-controlled feasibility trial of maraviroc plus optimised background therapy (OBT) versus OBT alone, in a 1:1 ratio, for people with virologically-suppressed HIV-1 and NAFLD without cirrhosis. Dosing followed recommendations for HIV therapy in the Summary of Product Characteristics for maraviroc.
Safeguarding is an important part of an orthodontist's working life, as such there are several organisations and a plethora of legislation. These strive to ensure orthodontists implement the safeguarding agenda in their working environment. This article will provide background information on safeguarding.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines methods for isolating fibroblasts from skin biopsies using different dissociation techniques (explant-based, enzymatic, and mechanical) combined with cryopreservation media to enhance cell viability and reprogramming into induced pluripotent stem cells (iPSCs).
- - Results showed that fibroblasts dissociated with explant-based or enzymatic methods exhibited better viability and growth, while explant-based dissociation led to slightly superior reprogramming quality for iPSC generation.
- - The research focuses on optimizing protocols for fibroblast processing to meet biobank accreditation standards, ensuring effective recovery and functionality of iPSCs derived from skin biopsy samples.
Although there are millions of formalin-fixed paraffin-embedded (FFPE) tissue blocks potentially available for scientific research, many are of questionable quality, partly due to unknown fixation conditions. We analyzed FFPE tissue biospecimens as part of the NCI Biospecimen Preanalytical Variables (BPV) program to identify microRNA (miRNA) markers for fixation time. miRNA was extracted from kidney and ovary tumor FFPE blocks (19 patients, cold ischemia ≤2 hours) with 6, 12, 24, and 72 hours fixation times, then analyzed using the WaferGen SmartChip platform (miRNA chip with 1036 miRNA targets).
View Article and Find Full Text PDFAim: This paper will discuss the process of action learning and the outcomes of using action learning as a tool to achieve a more strategic function from Nurse Consultant posts.
Background: It is documented that one of the most challenging aspect of Nurse Consultant roles, in terms of leadership, is the strategic contribution they make at a senior corporate Trust level, often across organizations and local health economies. A facilitated action learning set was established in Brighton, England, to support the strategic leadership development of eight nurse consultant posts across two NHS Trusts.