Use of gastrointestinal syndromic multiplex molecular assays and detection of pathotypes in pediatric wards.

pathotypes are enteric pathogens detected in gastrointestinal multiplex polymerase chain reaction (mPCR), with controversial clinical relevance. Our study aimed to describe clinical features and therapeutic decisions associated with detections in gastrointestinal mPCR. Children with positive mPCR for enteroaggregative (EAEC) enteropathogenic (EPEC) enterotoxigenic (ETEC), Shiga toxin-producing (STEC), and enteroinvasive (EIEC)/ identified in two pediatric hospitals over 18 months (2020-2021) were included.

Evaluation of Ceftazidime-avibactam and Ceftolozane-tazobactam Prescriptions in a Tertiary Hospital for Children in France: An Observational Study, 2017-2022.

Background: Infections caused by drug-resistant Gram-negative bacteria, including carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa, are emerging in pediatric hospitals. New ß-lactam/ ß-lactamase inhibitor combinations exhibit activity against these pathogens; however, there is limited data regarding their use in pediatric populations.

Objectives: The study aimed to describe the characteristics of ceftazidime-avibactam (CAZ/AVI) and ceftolozane-tazobactam (C/T) prescriptions in children and assess their appropriateness.