Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule β.

Scope: The food-associated mycotoxin deoxynivalenol (DON) is known to affect intestinal functions. However, its effect on intestinal mucus is poorly characterized.

Methods And Results: We analyzed the effects of DON on human goblet cells (HT29-16E cells) and porcine intestinal explants.