Saliva Samples as a Potential Tool for the Diagnosis and Monitoring of Cytomegalovirus Reactivation in Children Undergoing Transplantation.

Background: Regular monitoring of cytomegalovirus (CMV) reactivation in children who undergo transplantation is performed by molecular testing on blood samples. This highlights the need to explore noninvasive alternatives, such as saliva. The present study evaluated the usefulness of saliva samples for detecting and monitoring CMV reactivation in children undergoing transplantation at a referral center in Lima, Peru.

Haploidentical Stem Cell Transplantation With TCR αβ/CD19 Depletion in Children With Nonmalignant Hematologic Disorders: Outcomes From a Referral Center in Peru.

Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with TCR αβ/CD19 cell depletion is a promising therapeutic alternative for children with nonmalignant hematologic disorders, especially in low-income countries where finding a compatible donor is challenging. The use of this transplantation approach for nonmalignant hematologic disorders has not been previously described in the Peruvian pediatric population.

Methods: We present the outcomes of children under 19 with nonmalignant hematologic disorders who underwent haplo-HSCT with TCR αβ/CD19 cell depletion between 2018-2022 at a referral center in Lima, Peru.