Publications by authors named "Pauline Deshors"
Article Synopsis
- Glioblastoma (GBM) is a deadly brain cancer that often recurs due to the regrowth of cells that resist treatment and invade surrounding tissues.
- * Research shows that chemoradiation triggers a cell state called VC-Resist in GBM, which is more resistant to therapy and promotes tumor cell infiltration into the brain.
- * The VC-Resist state is linked to specific molecular features that enhance resistance, including DNA damage resistance and activation of pathways associated with stemness, ultimately complicating treatment efforts.
Glioblastomas (GBM) are aggressive brain tumours with a poor prognosis despite heavy therapy that combines surgical resection and radio-chemotherapy. The presence of a subpopulation of GBM stem cells (GSC) contributes to tumour aggressiveness, resistance and recurrence. Moreover, GBM are characterised by abnormal, abundant vascularisation.
View Article and Find Full Text PDFGlioblastomas (GBM) are brain tumors with a poor prognosis despite treatment that combines surgical resection and radio-chemotherapy. These tumors are characterized by abundant vascularization and significant cellular heterogeneity including GBM stem-like cells (GSC) which contribute to tumor aggressiveness, resistance, and recurrence. Recent data has demonstrated that GSC are directly involved in the formation of new vessels via their transdifferentiation into Tumor Derived Endothelial Cells (TDEC).
View Article and Find Full Text PDFGlioblastomas (GB) are malignant brain tumors with poor prognosis despite treatment with surgery and radio/chemotherapy. These tumors are defined by an important cellular heterogeneity and notably contain a subpopulation of GB-initiating cells (GIC), which contribute to tumor aggressiveness, resistance, and recurrence. Some integrins are specifically expressed by GICs and could be actionable targets to improve GB treatment.
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