Publications by authors named "Pauline Bourne"
Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group. It is an analogue of the insect steroid hormone 20-hydroxyecdysone. Previous ecdysteroid QSAR and molecular modelling studies predicted that the cavity of the ligand binding domain of the ecdysteroid receptor would possess space in the vicinity of C-11/C-12 of the ecdysteroid.
View Article and Find Full Text PDFArticle Synopsis
- Three new ecdysteroid compounds were created by modifying 11a-hydroxy ecdysteroids through dehydration.
- In biological tests using Drosophila cells, these modified compounds showed strong activity connected to their receptor affinity.
- When exposed to specific UV light, certain compounds significantly reduced binding sites for ecdysteroid receptors, indicating their potential use as photoaffinity tools for studying receptor interactions.